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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Head and neck squamous cell carcinoma: Ambiguous human papillomavirus status, elevated p16, and deleted retinoblastoma 1
Head & neck, v 39(3), pp E34-E39
01 Mar 2017
PMID: 27859938
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background. Head and neck squamous cell carcinoma (HNSCC) is potentially curable, but treatment planning remains a challenge. Oncogenic human papillomavirus (HPV)-positive disease is often associated with a good prognosis compared with HPV-negative disease. However, some HPV-positive HNSCC recurs, often with distant metastases and significant treatment resistance.
Methods and Results. We performed p16 immunohistochemistry (IHC), in situ hybridization (ISH) for high-risk HPV, and comprehensive genomic profiling on oropharyngeal HNSCC with basaloid features and particularly aggressive disease course, noting a rare genetic event: a deleting mutation (exons 5-17) of the tumor suppressor and dominant cell cycle regulator retinoblastoma 1 (RB1). Genomic and transcriptomic data available through FoundationOne and The Cancer Genome Atlas (TCGA) were reviewed for additional HNSCC cases with RB1 alterations.
Conclusion. RB1 alterations may have important prognostic implications, particularly in the context of high p16 expression, in both HPV-positive and HPV-negative HNSCC. (C) 2016 Wiley Periodicals, Inc.
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Details
- Title
- Head and neck squamous cell carcinoma: Ambiguous human papillomavirus status, elevated p16, and deleted retinoblastoma 1
- Creators
- Tim N. Beck - Fox Chase Cancer CenterChad H. Smith - Fox Chase Cancer CenterDouglas B. Flieder - Fox Chase Cancer CenterThomas J. Galloway - Fox Chase Cancer CenterJohn A. Ridge - Fox Chase Cancer CenterErica A. Golemis - Drexel UniversityRanee Mehra - Fox Chase Cancer Center
- Publication Details
- Head & neck, v 39(3), pp E34-E39
- Publisher
- Wiley
- Number of pages
- 6
- Grant note
- U54 CA149147; R21 CA181287; R21 CA191425; P50 CA083638 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA P30 CA006927 / National Cancer Institute Core Grant P50CA083638 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) F30 CA180607 / Ruth L. Kirschstein National Research Service Award F30 fellowship from the National Institutes of Health
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000397334700001
- Scopus ID
- 2-s2.0-84997771436
- Other Identifier
- 991019319070804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Otorhinolaryngology
- Surgery