Files and links (1)
Published, Version of Record (VoR)CC0 V1.0, Open
Journal article
Health-related quality of life among military HIV patients on antiretroviral therapy
PloS one, v 12(6), pp e0178953-e0178953
07 Jun 2017
PMID: 28591161
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective
The aims of this study were: (i) to determine the factors associated with HRQOL at baseline in our cohort, and (ii) to evaluate if there are differences in baseline HRQOL measures by antiretroviral treatment.
Methods
The Short Form 36 (SF-36) was administered between 2006 and 2010 among members of the United States HIV Natural History Study cohort (NHS), and participants who completed the SF-36 were included in the study. Physical component summary (PCS) and mental component summary (MCS) scores were computed based on standard algorithms. Multivariate linear regression models were constructed for PCS and MCS to estimate the association between selected variables and HRQOL scores.
Results
Antiretroviral therapy (ART) was not independently associated with HRQOL scores. Factors associated with PCS were CD4+ count <200 cells/mm(3) (beta = -5.84, 95% CI: -7.63, -4.06), mental comorbidity (beta = -2.82, 95% CI: -3.79, -1.85), medical comorbidity (beta = -2.51, 95% CI: -3.75, -1.27), AIDS diagnosis (beta = -2.38, 95% CI: -3.79, -0.98). Others were gender, military rank, marital status, and age. Factors independently associated with MCS were CD4+ count <200 cells/mm(3) (beta = -1.93, 95% CI: -3.85, -0.02), mental comorbidity (beta = -6.25, 95% CI: -7.25, -5.25), age (beta = 0.37, 95% CI: 0.14, 0.60), and being African American (beta = 1.55, 95% CI: 0.63, 2.47).
Conclusion
Among military active duty and beneficiaries with HIV, modifiable factors associated with HRQOL measures included advanced HIV disease, and mental or medical comorbidity. Addressing these factors may improve quality of life of HIV-infected individuals in the NHS cohort.
Metrics
Details
- Title
- Health-related quality of life among military HIV patients on antiretroviral therapy
- Creators
- Leonard Emuren - Drexel UniversitySeth Welles - Drexel UniversityAlison A. Evans - Drexel UniversityMarcia Polansky - Drexel UniversityJason F. Okulicz - Uniformed Services University of the Health SciencesGrace Macalino - Henry M. Jackson FoundationBrian K. Agan - Henry M. Jackson FoundationInfect Dis Clinical Res Program HI
- Publication Details
- PloS one, v 12(6), pp e0178953-e0178953
- Publisher
- Public Library Science
- Number of pages
- 17
- Grant note
- Y1-AI-5072 / National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) Infectious Disease Clinical Research Program (IDCRP), a Department of Defense (DoD) programthrough the Uniformed Services University of the Health Sciences
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]; Epidemiology and Biostatistics
- Web of Science ID
- WOS:000402880700062
- Scopus ID
- 2-s2.0-85020479702
- Other Identifier
- 991019167870904721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Infectious Diseases