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Journal article
Healthy Aging Interventions Reduce Repetitive Element Transcripts
The journals of gerontology. Series A, Biological sciences and medical sciences, v 76(5), pp 805-810
01 May 2021
PMID: 33257951
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Transcripts from noncoding repetitive elements (REs) in the genome may be involved in aging. However, they are often ignored in transcriptome studies on healthspan and lifespan, and their role in healthy aging interventions has not been characterized. Here, we analyze REs in RNA-seq datasets from mice subjected to robust healthspan- and lifespan-increasing interventions including calorie restriction, rapamycin, acarbose, 17-α-estradiol, and Protandim. We also examine RE transcripts in long-lived transgenic mice, and in mice subjected to a high-fat diet, and we use RNA-seq to investigate the influence of aerobic exercise on RE transcripts with aging in humans. We find that (a) healthy aging interventions/behaviors globally reduce RE transcripts, whereas aging and high-fat diet (an age-accelerating treatment) increase RE expression; and (b) reduced RE expression with healthy aging interventions is associated with biological/physiological processes mechanistically linked with aging. Our results suggest that RE transcript dysregulation and suppression are likely novel mechanisms underlying aging and healthy aging interventions, respectively.
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Details
- Title
- Healthy Aging Interventions Reduce Repetitive Element Transcripts
- Creators
- Devin Wahl - Colorado State UniversityAlyssa N Cavalier - Colorado State UniversityMeghan Smith - Colorado State UniversityDouglas R Seals - University of Colorado BoulderThomas J LaRocca - Colorado State University
- Publication Details
- The journals of gerontology. Series A, Biological sciences and medical sciences, v 76(5), pp 805-810
- Publisher
- Oxford University Press
- Grant note
- AG060302 / ; ;
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Health Sciences
- Web of Science ID
- WOS:000656221600008
- Scopus ID
- 2-s2.0-85106069189
- Other Identifier
- 991021894713204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Geriatrics & Gerontology
- Gerontology