Journal article
Heatr9is an infection responsive gene that affects cytokine production in alveolar epithelial cells
PLOS ONE, v 15(7), e0236195
17 Jul 2020
PMID: 32678841
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
During infection, viruses enter susceptible host cells in order to replicate their components for production of new virions. In the process of infection, the gene expression of infected cells undergoes changes because of the production of viral components and due to the host response from detection of viral products. In the advent of RNA sequencing, the discovery of new genes and their functions in the host response generates new avenues for interventions in the host-pathogen interaction. We have identified a novel gene,Heatr9, as a virus and cytokine inducible viral responsive gene. We confirmHeatr9's expressionin vitroandin vivoduring virus infection and correlate it with viral burden.Heatr9is induced by influenza virus and RSV.Heatr9knockdown during viral infection was shown to affect chemokine expression. Our studies identifyHeatr9as a novel inflammatory and virus infection induced gene that can regulate the induction of specific cytokines.
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Details
- Title
- Heatr9is an infection responsive gene that affects cytokine production in alveolar epithelial cells
- Publication Details
- PLOS ONE, v 15(7), e0236195
- Publisher
- PUBLIC LIBRARY SCIENCE; SAN FRANCISCO
- Grant note
- Financial support for these studies was not provided by any specific grant but funded by the department of Immunology of Erasmus University Medical Center, Rotterdam. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:000553920100001
- Scopus ID
- 2-s2.0-85088217976
- Other Identifier
- 991021860776004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology