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Heavy Metals in Breast Implants and Implications for Breast Implant Illness: A Systematic Review of the Literature
Journal article   Peer reviewed

Heavy Metals in Breast Implants and Implications for Breast Implant Illness: A Systematic Review of the Literature

Jade E Smith, Iulianna C Taritsa, Michael Stigliano, Jose Foppiani, Daniela Lee, Otakar Raska, Thomas Suszynski, Umar Choudry and Samuel J Lin
Aesthetic plastic surgery, v 49(19), pp 5472-5479
01 Oct 2025
DOI: https://doi.org/10.1007/s00266-025-04900-1
PMID: 40379928

Abstract

Breast Implantation - adverse effects Breast Implantation - instrumentation Breast Implants - adverse effects Female Humans Metals, Heavy - adverse effects Metals, Heavy - analysis
Breast implant illness (BII) has raised concerns about breast implant safety, with some suggesting that heavy metals released from implants could contribute to systemic symptoms. This systematic review examines the presence of metal residues in breast implants and surrounding tissues, and their potential role in BII. A systematic literature search following PRISMA guidelines was conducted using EMBASE, Web of Science, and PUBMED for studies published until January 2024. Inclusion criteria targeted material science and clinical research on metal residues in patients with breast implants. Data on metal concentrations, detection techniques, sample types, and clinical outcomes were extracted. Our search identified 304 titles, from which seven unique studies met inclusion criteria. Platinum, the most frequently detected metal, was detected in implant gel, capsular tissue, and systemic samples (blood, urine, and hair), in concentrations ranging from 0.001 to 125.27 μg/g. No consistent correlation was identified between metal levels and BII symptoms. Tin, aluminum, arsenic, and zinc were detected at low levels, below established toxicity thresholds, and often attributed to environmental exposure due to their presence in control groups. Inconsistencies in metal concentrations across studies were linked to variations in metal detection techniques and sample preparation. We highlight the presence of metal residues, particularly platinum, in breast implants and adjacent tissue, but without a definitive link to BII. Current evidence does not support heavy metal toxicity as a primary justification for total capsulectomy in BII management. Further evidence-based clinical guidelines are needed to better inform management of BII. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors   www.springer.com/00266 .

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being
#5 Gender Equality

Source: SDGs in the Output

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