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Helicobacter marmotae and novel Helicobacter and Campylobacter species isolated from the livers and intestines of prairie dogs
Journal article   Open access   Peer reviewed

Helicobacter marmotae and novel Helicobacter and Campylobacter species isolated from the livers and intestines of prairie dogs

Maike Beisele, Zeli Shen, Nicola Parry, Melissa Mobley, Nancy S. Taylor, Ellen Buckley, Mohammad Z. Abedin, Floyd E. Dewhirst and James G. Fox
Journal of medical microbiology, v 60(9), pp 1366-1374
01 Sep 2011
DOI: https://doi.org/10.1099/jmm.0.032144-0
PMID: 21546560
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
http://jmm.microbiologyresearch.org/deliver/fulltext/jmm/60/9/1366_jmm032144.pdf?itemId=/content/journal/jmm/10.1099/jmm.0.032144-0&mimeType=pdf&isFastTrackArticle=View
Published, Version of Record (VoR) Open

Abstract

Life Sciences & Biomedicine Microbiology Science & Technology
Prairie dogs (Cynomys ludovicianus) are used to study the aetiology and prevention of gallstones because of the similarities of prairie dog and human bile gallstone composition. Epidemiological and experimental studies have suggested a connection between infection with Helicobacter species and cholesterol cholelithiasis, cholecystis and gallbladder cancer. Ten of the 34 prairie dogs in this study had positive Helicobacter species identified by PCR using Helicobacter genus-specific primers. Ten of 34 prairie dogs had positive Campylobacter species identified in the intestine by PCR with Campylobacter genus-specific primers. Six Helicobacter sp. isolates and three Campylobacter sp. isolates were identified taxonomically by 16S rRNA gene analysis. The prairie dog helicobacters fell into three clusters adjacent to Helicobacter marmotae. On the basis of 16S rRNA gene sequence analysis, three strains in two adjacent clusters were included in the species H. marmotae. Three strains were only 97.1% similar to the sequence of H. marmotae and can be considered a novel species with the provisional designation Helicobacter sp. Prairie Dog 3. The prairie dog campylobacters formed a single novel cluster and represent a novel Campylobacter sp. with the provisional designation Campylobacter sp. Prairie Dog. They branched with Campylobacter cuniculorum at 96.3% similarity and had the greatest sequence similarity to Campylobacter helveticus at 97.1% similarity. Whether H. marmotae or the novel Helicobacter sp. and Campylobacter sp. identified in prairie dogs play a role in cholesterol gallstones or hepatobiliary disease requires further studies.

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19 citations in Web of Science
23 citations in Scopus

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UN Sustainable Development Goals (SDGs)

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#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
Web of Science research areas
Microbiology
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