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Journal article
Heme-Protein Interactions and Functional Relevant Heme Deformations: The Cytochrome c Case
Molecules (Basel, Switzerland), v 27(24), p8751
09 Dec 2022
PMID: 36557884
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Heme proteins are known to perform a plethora of biologically important functions. This article reviews work that has been conducted on various class I cytochrome c proteins over a period of nearly 50 years. The article focuses on the relevance of symmetry-lowering heme-protein interactions that affect the function of the electron transfer protein cytochrome c. The article provides an overview of various, mostly spectroscopic studies that explored the electronic structure of the heme group in these proteins and how it is affected by symmetry-lowering deformations. In addition to discussing a large variety of spectroscopic studies, the article provides a theoretical framework that should enable a comprehensive understanding of the physical chemistry that underlies the function not only of cytochrome c but of all heme proteins.
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Details
- Title
- Heme-Protein Interactions and Functional Relevant Heme Deformations: The Cytochrome c Case
- Creators
- Reinhard Schweitzer-Stenner - Department of Chemistry, Drexel University, Philadelphia, PA 19104, USA
- Publication Details
- Molecules (Basel, Switzerland), v 27(24), p8751
- Publisher
- MDPI
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemistry
- Web of Science ID
- WOS:000903327000001
- Scopus ID
- 2-s2.0-85144531847
- Other Identifier
- 991019442477104721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Chemistry, Multidisciplinary