Journal article
Hemodynamic Response to Repeated Noxious Cold Pressor Tests Measured by Functional Near Infrared Spectroscopy on Forehead
Annals of biomedical engineering, v 41(2), pp 223-237
Feb 2013
PMID: 22956158
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The objective of this research was to assess the utility of a simple near infrared spectroscopy (NIRS) technology for objective assessment of the hemodynamic response to acute pain. For this exploration, we used functional near infrared spectroscopy (fNIRS) to measure the hemodynamic response on the forehead during three trials of a cold pressor test (CPT) in 20 adults. To measure hemodynamic changes at the superficial tissues as well as the intracranial tissues, two configurations of ‘far’ and ‘near’ source-detector separations were used. We identified two features that were found to be fairly consistent across all subjects. The first feature was the change of total hemoglobin (THb) concentration in a given condition divided by the duration of that condition
$$ {\text{THb}}^{\prime} $$
. Statistical analyses revealed that during the first CPT trial
$$ {\text{THb}}^{\prime} $$
significantly changed from its baseline value in all channels. Also, adaptation to repeated CPTs was observed in both
$$ {\text{THb}}^{\prime} $$
parameter and the reported post-stimulus pain rating scores. The second feature was the difference between the maximum and the minimum of the evoked changes in the THb concentration (ΔTHb). A significant correlation was observed between the post-stimulus pain rating score and ΔTHb at all channels. An asymmetrical activity was observed only at the ‘far’ channels. These results suggest that fNIRS can potentially be used as a reliable technique for the assessment of the hemodynamic response to tonic pain induced by the CPT.
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Details
- Title
- Hemodynamic Response to Repeated Noxious Cold Pressor Tests Measured by Functional Near Infrared Spectroscopy on Forehead
- Creators
- Zeinab Barati - School of Biomedical Engineering, Science and Health Systems Drexel University 3141 Chestnut St., Bossone Research, Suite 718 Philadelphia PA 19104 USAPatricia Shewokis - College of Nursing and Health Professions Drexel University Philadelphia PA 19102 USAMeltem Izzetoglu - School of Biomedical Engineering, Science and Health Systems Drexel University 3141 Chestnut St., Bossone Research, Suite 718 Philadelphia PA 19104 USARobi Polikar - Department of Electrical and Computer Engineering Rowan University Glassboro NJ 08028 USAGeorge Mychaskiw - Department of Anesthesia Nemours Children’s Hospital Orlando FL 32827 USAKambiz Pourrezaei - School of Biomedical Engineering, Science and Health Systems Drexel University 3141 Chestnut St., Bossone Research, Suite 718 Philadelphia PA 19104 USA
- Publication Details
- Annals of biomedical engineering, v 41(2), pp 223-237
- Publisher
- Springer US; Boston
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; Nutrition Sciences
- Web of Science ID
- WOS:000313432200002
- Scopus ID
- 2-s2.0-84878504546
- Other Identifier
- 991014878337104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Biomedical