Journal article
Hemoglobin Concentration and Cognitive Impairment in the Renal REasons for Geographic And Racial Differences in Stroke (REGARDS) Study
The journals of gerontology. Series A, Biological sciences and medical sciences, v 65A(12), pp 1380-1386
Dec 2010
PMID: 20634281
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Abstract
Background. There is growing interest in determining the degree of anemia, which is clinically significant. The goal of this study was to determine the association between hemoglobin concentration and cognitive impairment in a large sample of U.S. adults. Methods. We used cross-sectional data from 19,701 adults participating in the REasons for Geographic And Racial Differences in Stroke study. Cognitive impairment was defined as a score of 4 or less on the six-item screener. Hemoglobin was analyzed in 1 g/dL increments relative to the World Health Organization (WHO) threshold (<13 g/dL for men and <12 g/dL for women). Results. The mean hemoglobin concentration was 13.7 ± 1.5 g/dL. The prevalence of cognitive impairment increased from 4.3% among individuals with a hemoglobin >3 g/dL above the WHO threshold to 16.8% for those with a hemoglobin ≥2 g/dL below the WHO threshold. After adjustment for demographics, chronic health conditions, health status, and inflammation, the association between reduced hemoglobin and cognitive impairment was attenuated and no longer significant, including among those with hemoglobin ≥2 g/dL below the WHO threshold (odds ratio 1.39, 95% confidence interval = 0.94–2.04). A test for linear trend was of borderline significance (p value = .06). For 94% of the sample within 2 g/dL of the WHO threshold, there was no relationship between hemoglobin concentration and the odds of cognitive impairment. The associations did not differ by sex and race. Conclusions. Within a large sample of community-dwelling adults, there was no significant association between hemoglobin concentration and cognitive impairment after multivariable adjustment.
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Details
- Title
- Hemoglobin Concentration and Cognitive Impairment in the Renal REasons for Geographic And Racial Differences in Stroke (REGARDS) Study
- Creators
- Manjula Kurella Tamura - Division of Nephrology, Department of Medicine, Stanford University School of Medicine, Palo Alto, CaliforniaVirginia G. Wadley - University of Alabama at BirminghamBritt B. Newsome - Colorado Kidney CareNeil A. Zakai - University of VermontLeslie A. McClure - Department of Biostatistics, School of Public Health andGeorge Howard - Department of Biostatistics, School of Public Health andDavid G. Warnock - University of Alabama at BirminghamWilliam McClellan - Emory University
- Publication Details
- The journals of gerontology. Series A, Biological sciences and medical sciences, v 65A(12), pp 1380-1386
- Publisher
- Oxford University Press
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000284639700014
- Scopus ID
- 2-s2.0-78649600108
- Other Identifier
- 991019231649704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Geriatrics & Gerontology
- Gerontology