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Journal article
Hemorheological Alteration in Patients Clinically Diagnosed with Chronic Liver Diseases
Journal of Korean medical science, v 31(12), pp 1943-1948
Dec 2016
PMID: 27822933
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Since liver function is changed by chronic liver diseases, chronic liver disease can lead to different hemorheological alterations during the course of the progression. This study aims to compare alterations in whole blood viscosity in patients with chronic liver disease, focusing on the gender effect. Chronic liver diseases were classified into three categories by patient's history, serologic markers, and radiologic findings: nonalcoholic fatty liver disease (NAFLD) (n = 63), chronic viral hepatitis B and C (n = 50), and liver cirrhosis (LC) (n = 35). Whole blood viscosity was measured by automated scanning capillary tube viscometer, while liver stiffness was measured by transient elastography using FibroScan®. Both systolic and diastolic whole blood viscosities were significantly lower in patients with LC than NAFLD and chronic viral hepatitis (P < 0.001) in male patients, but not in female patients. In correlation analysis, there were inverse relationships between both systolic and diastolic whole blood viscosity and liver stiffness (systolic: r = -0.25, diastolic: r = -0.22). Whole blood viscosity was significantly lower in male patients with LC than NAFLD or chronic viral hepatitis. Our data suggest that whole blood viscosity test can become a useful tool for classifying chronic liver disease and determining the prognosis for different types of chronic liver diseases.
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Details
- Title
- Hemorheological Alteration in Patients Clinically Diagnosed with Chronic Liver Diseases
- Creators
- Bohyun Jang - Seoul St. Mary's HospitalJi Won Han - Seoul St. Mary's HospitalPil Soo Sung - Seoul St. Mary's HospitalJeong Won Jang - Seoul St. Mary's HospitalSi Hyun Bae - Seoul St. Mary's HospitalJong Young Choi - Seoul St. Mary's HospitalYoung I Cho - Drexel UniversitySeung Kew Yoon - Seoul St. Mary's Hospital
- Publication Details
- Journal of Korean medical science, v 31(12), pp 1943-1948
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000390104800014
- Scopus ID
- 2-s2.0-84995570225
- Other Identifier
- 991019167439604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Peripheral Vascular Disease