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Heparin-Induced Thrombocytopenia: A Spectrum of Hemorrhage and Thrombosis—Case Presentations
Journal article   Peer reviewed

Heparin-Induced Thrombocytopenia: A Spectrum of Hemorrhage and Thrombosis—Case Presentations

Louis E. Samuels, Arthur Shektman, George Amrom, Robert J. DiGiovanai, Jean-Rene Dupont and Morris D. Kerstein
Vascular surgery, v 26(7), pp 596-604
Sep 1992
DOI: https://doi.org/10.1177/153857449202600714
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Three cases of the heparin-induced thrombocytopenia syndrome are presented. Two of the patients died of thrombotic sequelae and 1 patient survived but suffered a significant bleeding complication. Several significant features are identified: (1) clinical presentation of the syndrome was apparent just before a fall in the platelet count; (2) platelet counts below 100,000/mm 3 were not necessary for complications to occur; (3) antiplatelet IgM antibody was identified with the bleeding complication, as opposed to IgG in the thrombotic complication ; (4) despite cessation of heparin and institution of coumadin in 1 patient, platelet counts remained depressed and thrombotic complications continued to occur; and (5) superior vena cava thrombosis occurred in 1 patient, a condition previously unreported. These findings offer a means of suspecting the diagnosis before complications occur, raise questions regarding mechanism and management of the disorder, and add to the spectrum of thrombohemorrhagic sequelae associated with this syndrome.

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3 citations in Web of Science
3 citations in Scopus

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UN Sustainable Development Goals (SDGs)

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#3 Good Health and Well-Being

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Web of Science research areas
Peripheral Vascular Disease
Surgery
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