Journal article
Hepatitis B Virus X and Regulation of Viral Gene Expression
Cold Spring Harbor perspectives in medicine, v 6(3), pp a021402-a021402
08 Jan 2016
PMID: 26747833
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The efficient replication of hepatitis B virus (HBV) requires the HBV regulatory hepatitis B virus X (HBx) protein. The exact contributions of HBx are not fully understood, in part because of the limitations of the assays used for its study. When HBV replication is driven from a plasmid DNA, the contribution of HBx is modest. However, there is an absolute requirement for HBx in assays that recapitulate the infectious virus life cycle. There is much evidence that HBx can contribute directly to HBV replication by acting on viral promoters embedded within protein coding sequences. In addition, HBx may also contribute indirectly by modulating cellular pathways to benefit virus replication. Understanding the mechanism(s) of HBx action during virus replication may provide insight into novel ways to disrupt chronic HBV replication.
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Details
- Title
- Hepatitis B Virus X and Regulation of Viral Gene Expression
- Creators
- Betty L Slagle - Baylor College of MedicineMichael J Bouchard - Drexel University
- Publication Details
- Cold Spring Harbor perspectives in medicine, v 6(3), pp a021402-a021402
- Publisher
- American Physical Society (APS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000371175800007
- Scopus ID
- 2-s2.0-84959534685
- Other Identifier
- 991019168211104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Medicine, Research & Experimental