Journal article
Hepatitis B and C virus infection and diabetes mellitus: A cohort study
Scientific reports, v 7(1), 4606
04 Jul 2017
PMID: 28676706
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The role of hepatitis virus infection in glucose homeostasis is uncertain. We examined the associations between hepatitis B virus (HBV) or hepatitis C virus (HCV) infection and the development of diabetes in a cohort (N = 439,708) of asymptomatic participants in health screening examinations. In crosssectional analyses, the multivariable-adjusted odds ratio for prevalent diabetes comparing hepatitis B surface antigen (HBsAg) (+) to HBsAg (-) participants was 1.17 (95% CI 1.06-1.31; P = 0.003). The corresponding odds ratio comparing hepatitis C antibodies (HCV Ab) (+) to HCV Ab (-) participants was 1.43 (95% CI 1.01-2.02, P = 0.043). In prospective analyses, the multivariable-adjusted hazard ratio for incident diabetes comparing HBsAg (+) to HbsAg (-) participants was 1.23 (95% CI 1.08-1.41; P = 0.007). The number of incident cases of diabetes among HCV Ab (+) participants (10 cases) was too small to reliably estimate the prospective association between HCV infection and diabetes. In this large population at low risk of diabetes, HBV and HCV infections were associated with diabetes prevalence and HBV infection with the risk of incident diabetes. Our studies add evidence suggesting that diabetes is an additional metabolic complication of HBV and HCV infection.
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Details
- Title
- Hepatitis B and C virus infection and diabetes mellitus: A cohort study
- Creators
- Yun Soo Hong - Johns Hopkins UniversityYoosoo Chang - Kangbuk Samsung HospitalSeungho Ryu - Kangbuk Samsung HospitalMiguel Cainzos-Achirica - Johns Hopkins UniversityMin-Jung Kwon - Sungkyunkwan UniversityYiyi Zhang - Johns Hopkins UniversityYuni Choi - Kangbuk Samsung HospitalJiin Ahn - Kangbuk Samsung HospitalSanjay Rampal - University of MalayaDi Zhao - Johns Hopkins UniversityRoberto Pastor-Barriuso - Centro de Investigación Biomédica en Red de Epidemiología y Salud PúblicaMariana Lazo - Johns Hopkins UniversityHocheol Shin - Kangbuk Samsung HospitalJuhee Cho - Sungkyunkwan UniversityEliseo Guallar - Johns Hopkins University
- Publication Details
- Scientific reports, v 7(1), 4606
- Publisher
- Springer Nature
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000404657300001
- Scopus ID
- 2-s2.0-85021713950
- Other Identifier
- 991020550343604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Gastroenterology & Hepatology