Journal article
Hepatitis B and D genomes in hepatitis B surface antigen negative patients with chronic hepatitis C
Journal of medical virology, v 45(2), pp 168-173
Feb 1995
PMID: 7539829
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
<p>Hepatitis B and hepatitis D viral genomes were tested by nested polymerase chain reaction in the serum and liver of 69 hepatitis B surface antigen (HBsAg) negative, anti-hepatitis C virus (HCV) positive patients (47 with HCV RNA and 22 without HCV RNA). Serum hepatitis B virus (HBV) DNA-was detected in 49% of the patients with HCV-RNA and in 64% of those without HCV-RNA. Furthermore, intrahepatic HBV-DNA was found in four of five (80%) of the biopsies analysed. Delta genome was found in 72% and 73%, respectively, of the anti-HCV positive patients with or without HCV-RNA. In addition, intrahepatic delta virus genome was detected in another four liver biopsies studied. In the group of patients with HCV-RNA, the simultaneous presence of hepatitis B and D genomes was statistically higher in transfused patients than in drug addicts, or in those with an unknown infection route (P < 0.001). These results show a high percentage of B and D genomes in HBsAg negative patients with anti-HCV, irrespective of the presence or absence of the HCV genome. However, the clinical implications of this finding should be examined in future studies. (C) 1995 Wiley-Liss, Inc.</p>
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Details
- Title
- Hepatitis B and D genomes in hepatitis B surface antigen negative patients with chronic hepatitis C
- Creators
- Sara González - Hospital Universitario Fundación Jiménez DíazAntonio Madejón - Hospital Universitario Fundación Jiménez DíazJavier Bartolomé - Hospital Universitario Fundación Jiménez DíazInmaculada Castillo - Hospital Universitario Fundación Jiménez DíazGloria Moraleda - Hospital Universitario Fundación Jiménez DíazJulio Martín - Fundación para el Estudio de las Hepatitis ViralesEduardo Marriott - Hospital Universitario Fundación Jiménez DíazMontserrat Herrero - Hepatology Unit, Fundación Jiménez Diaz, Madrid, SpainSonia Navas-Martin - Drexel University, Microbiology and ImmunologyVicente Carreño - Fundación para el Estudio de las Hepatitis Virales
- Publication Details
- Journal of medical virology, v 45(2), pp 168-173
- Publisher
- Wiley
- Number of pages
- 6
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:A1995QK14600009
- Scopus ID
- 2-s2.0-0028986018
- Other Identifier
- 991022047818504721
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- Web of Science research areas
- Virology