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Journal article
Hepatitis B and Hepatitis C Virus Replication Upregulates Serine Protease Inhibitor Kazal, Resulting in Cellular Resistance to Serine Protease-Dependent Apoptosis
Journal of virology, v 84(2), pp 907-917
15 Jan 2010
PMID: 19864383
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Hepatitis B and C viruses (HBV and HCV, respectively) are different and distinct viruses, but there are striking similarities in their disease potential. Infection by either virus can cause chronic hepatitis, liver cirrhosis, and ultimately, liver cancer, despite the fact that no pathogenetic mechanisms are known which are shared by the two viruses. Our recent studies have suggested that replication of either of these viruses upregulates a cellular protein called serine protease inhibitor Kazal (SPIK). Furthermore, the data have shown that cells containing HBV and HCV are more resistant to serine protease-dependent apoptotic death. Since our previous studies have shown that SPIK is an inhibitor of serine protease-dependent apoptosis, it is hypothesized that the upregulation of SPIK caused by HBV and HCV replication leads to cell resistance to apoptosis. The evasion of apoptotic death by infected cells results in persistent viral replication and constant liver inflammation, which leads to gradual accumulation of genetic changes and eventual development of cancer. These findings suggest a possibility by which HBV and HCV, two very different viruses, can share a common mechanism in provoking liver disease and cancer.
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Details
- Title
- Hepatitis B and Hepatitis C Virus Replication Upregulates Serine Protease Inhibitor Kazal, Resulting in Cellular Resistance to Serine Protease-Dependent Apoptosis
- Creators
- Jason Lamontagne - Drexel UniversityMark Pinkerton - Delaware Valley CollegeTimothy M. Block - Drexel UniversityXuanyong Lu - Drexel University
- Publication Details
- Journal of virology, v 84(2), pp 907-917
- Publisher
- Amer Soc Microbiology
- Number of pages
- 11
- Grant note
- Commonwealth of Pennsylvania Hepatitis B Foundation National Cancer Institute, NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000272994300022
- Scopus ID
- 2-s2.0-73849109817
- Other Identifier
- 991019167599604721
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- Web of Science research areas
- Virology