Journal article
Hepatitis B care cascade among people with HIV/HBV coinfection in the North American AIDS Cohort Collaboration on Research and Design, 2012-2016
PloS one, v 18(9), 0290889
01 Sep 2023
PMID: 37656704
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A care cascade is a critical tool for evaluating delivery of care for chronic infections across sequential stages, starting with diagnosis and ending with viral suppression. However, there have been few data describing the hepatitis B virus (HBV) care cascade among people living with HIV infection who have HBV coinfection. We conducted a cross-sectional study among people living with HIV and HBV coinfection receiving care between January 1, 2012 and December 31, 2016 within 13 United States and Canadian clinical cohorts contributing data to the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD). We evaluated each of the steps in this cascade, including: 1) laboratory-confirmed HBV infection, 2) tenofovir-based or entecavir-based HBV therapy prescribed, 3) HBV DNA measured during treatment, and 4) viral suppression achieved via undetectable HBV DNA. Among 3,953 persons with laboratory-confirmed HBV (median age, 50 years; 6.5% female; 43.8% were Black; 7.1% were Hispanic), 3,592 (90.9%; 95% confidence interval, 90.0-91.8%) were prescribed tenofovir-based antiretroviral therapy or entecavir along with their antiretroviral therapy regimen, 2,281 (57.7%; 95% confidence interval, 56.2-59.2%) had HBV DNA measured while on therapy, and 1,624 (41.1%; 95% confidence interval, 39.5-42.6) achieved an undetectable HBV DNA during HBV treatment. Our study identified significant gaps in measurement of HBV DNA and suppression of HBV viremia among people living with HIV and HBV coinfection in the United States and Canada. Periodic evaluation of the HBV care cascade among persons with HIV/HBV will be critical to monitoring success in completion of each step.
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Details
- Title
- Hepatitis B care cascade among people with HIV/HBV coinfection in the North American AIDS Cohort Collaboration on Research and Design, 2012-2016
- Creators
- Jessica Kim - Drexel UniversityCraig W. Newcomb - College Station Medical CenterDena M. Carbonari - College Station Medical CenterJessie Torgersen - College Station Medical CenterKeri N. Althoff - Johns Hopkins UniversityMari M. Kitahata - University of WashingtonMarina B. Klein - McGill UniversityRichard D. Moore - Johns Hopkins UniversityK. Rajender Reddy - College Station Medical CenterMichael J. Silverberg - Kaiser PermanenteAngel M. Mayor - Univ Cent Caribe, Retrovirus Res Ctr, Bayamon, PR USAMichael A. Horberg - College Station Medical CenterEdward R. Cachay - Univ Calif San Diego, Dept Med, La Jolla, CA USAJoseph K. Lim - College Station Medical CenterM. John Gill - University of CalgaryKara Chew - Univ Calif Los Angeles, Dept Med, Los Angeles, CA USATimothy R. Sterling - Vanderbilt UniversityMark Hull - University of British ColumbiaEric C. Seaberg - Johns Hopkins UniversityGregory D. Kirk - Johns Hopkins UniversitySally B. Coburn - Johns Hopkins UniversityRaynell Lang - University of CalgaryKathleen A. Mcginnis - VA Connecticut Healthcare Syst, West Haven, CT USAKelly A. Gebo - Johns Hopkins UniversitySonia Napravnik - Univ North Carolina Chapel Hill, Dept Med, Chapel Hill, NC USAH. Nina Kim - University of WashingtonVincent Lo Re - College Station Medical CenterNorth Amer AIDS Cohort Collabor
- Publication Details
- PloS one, v 18(9), 0290889
- Publisher
- Public Library Science
- Number of pages
- 11
- Grant note
- Southern Alberta Clinic Cohort: M. John Gill
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:001066578500009
- Scopus ID
- 2-s2.0-85169517220
- Other Identifier
- 991022207162604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Gastroenterology & Hepatology