Journal article
Hepatitis B virus infection and development of chronic kidney disease: a cohort study
BMC nephrology, v 19(1), pp 353-353
11 Dec 2018
PMID: 30537940
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
BackgroundThe effect of chronic hepatitis B virus (HBV) infection on the risk of chronic kidney disease (CKD) is controversial. We examined the prospective association between hepatitis B surface antigen (HBsAg) serology status and incident CKD in a large cohort of men and women.MethodsCohort study of 299,913 adults free of CKD at baseline who underwent health screening exams between January 2002 and December 2016 in South Korea. Incident CKD was defined as the development of an estimated glomerular filtration rate (eGFR)<60ml/min/1.73m(2) and/or proteinuria.ResultsOver 1,673,701 person-years of follow-up, we observed 13,924 incident cases of CKD (3225 cases of eGFR <60ml/min/1.73m(2) and 11,072 cases of proteinuria). In fully adjusted models comparing positive to negative HBsAg participants, the hazard ratio (HR, 95% confidence interval) for incident CKD was 1.11 (1.03-1.21; P=0.01). The corresponding HR for incident proteinuria and for eGFR <60ml/min/1.73m(2) were 1.23 (1.12-1.35; P<0.001) and 0.89 (0.73-1.07; P=0.21), respectively. The associations were similar across categories of liver enzyme levels at baseline.ConclusionIn this large cohort, HBsAg positive serology was associated with higher risk of incident CKD, and we provide novel evidence that this association was due to a higher incidence of proteinuria in HBsAg positive participants. Our study adds to the growing body of evidence suggesting that chronic HBV infection may be a contributor to the increasing incidence of CKD.
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Details
- Title
- Hepatitis B virus infection and development of chronic kidney disease: a cohort study
- Creators
- Yun Soo Hong - Johns Hopkins UniversitySeungho Ryu - Kangbuk Samsung HospitalYoosoo Chang - Kangbuk Samsung HospitalMiguel Cainzos-Achirica - Johns Hopkins UniversityMin-Jung Kwon - Sungkyunkwan UniversityDi Zhao - Johns Hopkins UniversityTariq Shafi - Johns Hopkins UniversityMariana Lazo - Johns Hopkins UniversityRoberto Pastor-Barriuso - Centro de Investigación Biomédica en Red de Epidemiología y Salud PúblicaHocheol Shin - Kangbuk Samsung HospitalJuhee Cho - Johns Hopkins UniversityEliseo Guallar - Johns Hopkins University
- Publication Details
- BMC nephrology, v 19(1), pp 353-353
- Publisher
- Springer Nature
- Number of pages
- 8
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000452839000003
- Scopus ID
- 2-s2.0-85058284032
- Other Identifier
- 991020550499604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Urology & Nephrology