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Hepatitis C Virus Protease Gene Diversity in Patients Coinfected with Human Immunodeficiency Virus
Journal article   Open access   Peer reviewed

Hepatitis C Virus Protease Gene Diversity in Patients Coinfected with Human Immunodeficiency Virus

Mark A. Winters, Seth L. Welles and Mark Holodniy
Journal of virology, v 80(8), pp 4196-4199
01 Apr 2006
DOI: https://doi.org/10.1128/JVI.80.8.4196-4199.2006
PMID: 16571838
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://europepmc.org/articles/pmc1440459View
Published, Version of Record (VoR)Open Access (License Unspecified),  Open

Abstract

Genetic Diversity and Evolution
The clonal variability of the hepatitis C virus (HCV) protease gene in 24 individuals with HCV genotypes 1a, 1b, 2b, and 3a who were coinfected with the human immunodeficiency virus was evaluated. Within-genotype variability at the nucleotide and amino acid levels ranged from 6.5 to 8.6% and 2.2 to 3.8%, respectively. After adjustments were made for correlation of intrapatient clonal variation, mixed-model analysis indicated that nucleotide and amino acid variability among patients with different genotypes did not differ significantly. However, within individual patients, clonal variability differed by up to 5.3% and 5.8% at the nucleotide and amino acid levels, respectively, and genotype 1a had significantly greater nucleotide variability than other genotypes (P= 0.01). Significant variability exists within HCV protease gene variants at the patient level and could affect the effectiveness of HCV protease inhibitors.

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9 citations in Web of Science
10 citations in Scopus

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UN Sustainable Development Goals (SDGs)

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Collaboration types
Domestic collaboration
Web of Science research areas
Virology
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