Journal article
Hepatitis C virus core protein enhances HIV-1 replication in human macrophages through TLR2, JNK, and MEK1/2-dependent of TNF-alpha and IL-6
FEBS letters, v 588(18), pp 3501-3510
17 Sep 2014
PMID: 25131930
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Despite their differential cell tropisms, HIV-1 and HCV dramatically influence disease progression in coinfected patients. Macrophages are important target cells of HIV-1. We hypothesized that secreted HCV core protein might modulate HIV-1 replication. We demonstrate that HCV core significantly enhances HIV-1 replication in human macrophages by upregulating TNF-alpha and IL-6 via TLR2-, JNK-, and MEK1/2-dependent pathways. Furthermore, we show that TNF-alpha and IL-6 secreted from HCV core-treated macrophages reactivates monocytic U1 cells latently infected with HIV-1. Our studies reveal a previously unrecognized role of HCV core by enhancing HIV-1 infection in macrophages. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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Details
- Title
- Hepatitis C virus core protein enhances HIV-1 replication in human macrophages through TLR2, JNK, and MEK1/2-dependent of TNF-alpha and IL-6
- Creators
- Gokul Swaminathan - Drexel UniversityDaniel Pascual - Drexel UniversityGermaine Rival - Drexel UniversityRenzo Perales-Linares - Drexel UniversityJulio Martin-Garcia - Drexel UniversitySonia Navas-Martin - Drexel University
- Publication Details
- FEBS letters, v 588(18), pp 3501-3510
- Publisher
- Elsevier
- Number of pages
- 10
- Grant note
- R21AI098549 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) AI088423; DK089314; NS065727; AI098549 / National Institute of Allergy and Infectious Disease (AI) National Institute of Neurological Disorders and Stroke (NS) R21DK089314 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) R01NS065727 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) National Institute of Diabetes and Digestive and Kidney Diseases (DK); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000341450600027
- Scopus ID
- 2-s2.0-84908691390
- Other Identifier
- 991019168558604721
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- Web of Science research areas
- Biochemistry & Molecular Biology
- Biophysics
- Cell Biology