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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Hepcidin, an Iron Regulatory Hormone of Innate Immunity, is Differentially Expressed in Premature Fetuses with Early-Onset Neonatal Sepsis
American journal of perinatology, v 35(9), pp 865-872
Jul 2018
PMID: 29532452
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Abstract
Objective
Hepcidin, a mediator of innate immunity, binds the iron exporter ferroportin, leading to functional hypoferremia through intracellular iron sequestration. We explored hepcidin–ferroportin interactions in neonates clinically diagnosed with early-onset neonatal sepsis (EONS).
Study Design
Hepcidin and interleukin (IL)-6 were quantified by enzyme-linked immunosorbent assay (ELISA) in 92 paired cord blood–maternal blood samples in the following groups: “Yes” EONS (
n
= 41, gestational age [GA] 29 ± 1 weeks) and “No” EONS (
n
= 51, GA 26 ± 1 weeks). Placental hepcidin and ferroportin expression were evaluated by immunohistochemistry and real-time-polymerase chain reaction (RT-PCR). Liver hepcidin and ferroportin expression patterns were ascertained in autopsy specimens of neonates (
n
= 8) who died secondary to culture-proven sepsis.
Results
Cord blood hepcidin was significantly elevated (GA corrected,
p
= 0.018) and was positively correlated with IL-6 (
r
= 0.379,
p
= 0.001) in EONS. Hepcidin localized at syncytiotrophoblast and fetal vascular endothelium. Placental ferroportin, but not hepcidin mRNA correlated with cord blood hepcidin levels (
r
= 0.46,
p
= 0.039) and funisitis severity (
r
= 0.50,
p
= 0.018). Newborns who died from sepsis (
n
= 4) had higher hepatic hepcidin and iron sequestration, but lower ferroportin staining than those who died of nonsepsis causes (
n
= 4).
Conclusion
Premature fetuses with EONS have elevated circulating hepcidin, likely related to lower placenta and liver ferroportin expression. Fetal hepcidin–ferroportin interaction appears to play a role in EONS pathophysiology independent of maternal response to intrauterine inflammation.
Metrics
Details
- Title
- Hepcidin, an Iron Regulatory Hormone of Innate Immunity, is Differentially Expressed in Premature Fetuses with Early-Onset Neonatal Sepsis
- Creators
- Sammy M. Tabbah - The Ohio State UniversityCatalin S. Buhimschi - The Ohio State UniversityKatherine Rodewald-Millen - The Ohio State UniversityChristopher R. Pierson - Nationwide Children's HospitalVineet Bhandari - Drexel UniversityPhilip Samuels - The Ohio State UniversityIrina A. Buhimschi - The Research Institute at Nationwide Children's Hospital
- Publication Details
- American journal of perinatology, v 35(9), pp 865-872
- Publisher
- Thieme Medical Publishers
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000437856800009
- Scopus ID
- 2-s2.0-85041629533
- Other Identifier
- 991019167522904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Obstetrics & Gynecology
- Pediatrics