Journal article
Herbicide use in farming and other jobs in relation to non-Hodgkin’s lymphoma (NHL) risk
Occupational and environmental medicine (London, England), v 79(12), pp 795-806
07 Oct 2022
PMID: 36207110
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
ObjectivesGiven mixed evidence for carcinogenicity of current-use herbicides, we studied the relationship between occupational herbicide use and risk of non-Hodgkin’s lymphoma (NHL) in a large, pooled study.MethodsWe pooled data from 10 case-control studies participating in the International Lymphoma Epidemiology Consortium, including 9229 cases and 9626 controls from North America, the European Union and Australia. Herbicide use was coded from self-report or by expert assessment in the individual studies, for herbicide groups (eg, phenoxy herbicides) and active ingredients (eg, 2,4-dichlorophenoxyacetic acid (2,4-D), glyphosate). The association between each herbicide and NHL risk was estimated using logistic regression to produce ORs and 95% CIs, with adjustment for sociodemographic factors, farming and other pesticides.ResultsWe found no substantial association of all NHL risk with ever-use of any herbicide (OR=1.10, 95% CI: 0.94 to 1.29), nor with herbicide groups or active ingredients. Elevations in risk were observed for NHL subtypes with longer duration of phenoxy herbicide use, such as for any phenoxy herbicide with multiple myeloma (>25.5 years, OR=1.78, 95% CI: 0.74 to 4.27), 2,4-D with diffuse large B-cell lymphoma (>25.5 years, OR=1.47, 95% CI: 0.67 to 3.21) and other (non-2,4-D) phenoxy herbicides with T-cell lymphoma (>6 years, lagged 10 years, OR=3.24, 95% CI: 1.03 to 10.2). An association between glyphosate and follicular lymphoma (lagged 10 years: OR=1.48, 95% CI: 0.98 to 2.25) was fairly consistent across analyses.ConclusionsMost of the herbicides examined were not associated with NHL risk. However, associations of phenoxy herbicides and glyphosate with particular NHL subtypes underscore the importance of estimating subtype-specific risks.
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Details
- Title
- Herbicide use in farming and other jobs in relation to non-Hodgkin’s lymphoma (NHL) risk
- Creators
- Anneclaire J De Roos - Drexel UniversityLin Fritschi - Curtin UniversityMary H Ward - National Institutes of HealthAlain Monnereau - Sorbonne Paris CitéJonathan Hofmann - National Institutes of HealthLeslie Bernstein - Division of Biomarkers of Early Detection and Prevention, Beckman Research Institute of City of Hope, City of Hope Comprehensive Cancer Center, Duarte, California, USAParveen Bhatti - Cancer Control Research, BC Cancer, Vancouver, British Columbia, CanadaYolanda Benavente Moreno - Instituto de Salud Carlos IIIGeza Benke - Monash UniversityDelphine Casabonne - Instituto de Salud Carlos IIIJacqueline Clavel - Sorbonne Paris CitéPierluigi Cocco - University of CagliariTran Huynh - Drexel UniversityAndrea 't Mannetje - Massey UniversityLucia Miligi - Florence (Netherlands)Sara Piro - Florence (Netherlands)Nathaniel Rothman - National Institutes of HealthLeah H Schinasi - Drexel UniversityClaire M Vajdic - UNSW SydneySophia S Wang - Division of Health Analytics, Department of Computational and Quantitative Medicine, City of Hope Comprehensive Cancer Center, Duarte, California, USAYawei Zhang - National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaSusan L Slager - Department of Medicine, Division of Hematology, Mayo Clinic, Rochester, Minnesota, USAJames R Cerhan - Division of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic College of Medicine, Rochester, Minnesota, USAFrench Network Canc Registries FRA
- Publication Details
- Occupational and environmental medicine (London, England), v 79(12), pp 795-806
- Publisher
- BMJ Publishing Group Ltd
- Grant note
- R03CA199515 / National Cancer Institute of the National Institutes of Health
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000866156600001
- Scopus ID
- 2-s2.0-85142401054
- Other Identifier
- 991019335488604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health