Journal article
Herpes simplex virus type 1 replication and IL-1β gene expression in mouse peritoneal macrophages activated in vivo by an attenuated Salmonella typhimurium vaccine or Corynebacterium parvum
Microbial pathogenesis, v 16(6), pp 387-399
1994
PMID: 7830526
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Activated macrophages (Mφ) from mice given
Salmonella typhimurium or
Corynebacterium parvum were compared with resident peritoneal macrophages at the molecular level for permissiveness for herpes simplex virus type 1 (HSV-1) replication and for expression of interleukin-1 beta (IL-1β). Peritoneal macrophages were harvested from mice injected 7 days previously with live, avirulent
S. typhimurium (Sal-PMφ) or heat-killed
C. parvum (CP-PMφ), and infected with HSV-1
in vitro. Both Sal-PMφ and CP-PMφ were activated as evidenced by characteristic changes in an ectoenzyme, by increased permissiveness for infectious virus production and viral cytopathic effect, and by induction of IL-1β mRNA. Analysis at the molecular level revealed that both types of activated Mφ demonstrated increased patterns of HSV-1 immediate-early gene expression and viral DNA replication as compared with resident cells. A novel finding was that viral infection reduced IL-1β mRNA in both types of activated Mβ. This observation has implications for the efficacy of Salmonella vaccines given in proximity to HSV-1 infection and for potential deleterious effects of HSV-1 infection in immunosuppressed patients receiving immunotherapy.
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Details
- Title
- Herpes simplex virus type 1 replication and IL-1β gene expression in mouse peritoneal macrophages activated in vivo by an attenuated Salmonella typhimurium vaccine or Corynebacterium parvum
- Creators
- Linxian Wu - Drexel UniversityPage S. Morahan - Drexel UniversityJill A. Hendrzak - Drexel UniversityToby K. Eisenstein - Drexel University
- Publication Details
- Microbial pathogenesis, v 16(6), pp 387-399
- Publisher
- Elsevier India Pvt Ltd
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:A1994PH25100001
- Scopus ID
- 2-s2.0-0028068502
- Other Identifier
- 991019184214404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology
- Microbiology