Files and links (1)
Accepted (AM)Open Access (License Unspecified), Open
Journal article
Herring roe oil supplementation alters microglial cell gene expression and reduces peripheral inflammation after immune activation in a neonatal piglet model
Brain, behavior, and immunity, v 81, pp 455-469
Oct 2019
PMID: 31271868
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
•Dietary herring roe oil increased DHA in the piglet occipital lobe.•Herring roe oil decreased arachidonic acid metabolites in the occipital lobe.•Herring roe oil decreased circulating neutrophils.•Herring roe oil did not affect ex vivo microglial pro-inflammatory cytokine production.•Genes CXCL16, TGFBR1, C1QA were upregulated by herring roe oil in microglial cells.
Neonatal brain development can be disrupted by infection that results in microglial cell activation and neuroinflammation. Studies indicate that polyunsaturated fatty acids (PUFAs) and their metabolites can resolve inflammation. It is not known if dietary PUFA increases lipid metabolites in brain or reduces neuroinflammation in neonates. We hypothesized that dietary PUFAs might suppress neuroinflammation by inhibiting pro-inflammatory cytokine over-production and promoting inflammatory resolution in the periphery and brain. Piglets were obtained on postnatal day (PD) 2 and randomly assigned to herring roe oil (HRO) or control (CON) diet. HRO was included at 2 g/kg powdered diet. HRO increased DHA levels in occipital lobe and the DHA to arachidonic acid (ARA) ratio in hippocampal tissue. HRO decreased ARA metabolites in occipital lobe. HRO failed to attenuate microglial pro-inflammatory cytokine production ex vivo. HRO did not affect fever or circulating resolvin D1 levels. HRO decreased circulating neutrophils and liver inflammatory gene expression, but increased resolution marker gene expression in liver post LPS. HRO upregulated CXCL16, TGFBR1, and C1QA in microglial cells. HRO supplementation exerted beneficial effects on inflammation in the periphery, but further studies are needed to evaluate the specific effects of omega-3 supplementation on microglial cell physiology in the neonate.
Metrics
Details
- Title
- Herring roe oil supplementation alters microglial cell gene expression and reduces peripheral inflammation after immune activation in a neonatal piglet model
- Creators
- Megan P. Caputo - Veterinary Medical Scholars Program, Office of Research and Advanced Studies, University of Illinois at Urbana-Champaign, College of Veterinary Medicine, 3505 VMBSB, 2001 South Lincoln Ave, Urbana, IL, 61802 USAEmily C. Radlowski - University of Illinois Urbana-ChampaignMarcus A. Lawson - University of Illinois Urbana-ChampaignAdrienne M. Antonson - University of Illinois Urbana-ChampaignJosephine E. Watson - University of Illinois Urbana-ChampaignStephanie M. Matt - University of Illinois Urbana-ChampaignBrian J. Leyshon - University of Illinois Urbana-ChampaignAditi Das - University of Illinois Urbana-ChampaignRodney W. Johnson - University of Illinois Urbana-Champaign
- Publication Details
- Brain, behavior, and immunity, v 81, pp 455-469
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000488135800049
- Scopus ID
- 2-s2.0-85068574747
- Other Identifier
- 991019167559904721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology
- Neurosciences
- Psychiatry