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Journal article
Heterogeneity of Anti-Phospholipid and Anti-Endothelial Cell Antibodies
Journal of autoimmunity, v 11(6), pp 651-660
Dec 1998
PMID: 9878087
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The role of the anti-phospholipid antibodies (APLA) and anti-endothelial cell antibodies (AECA) in the pathogenesis of anti-phospholipid syndrome (APS) is unclear. Differences in the reported involvement of APLA may be due, in part, to the polyclonal nature of these antibodies and the use of serum and serum fractions for analysis. To circumvent this issue, we generated monoclonal antibodies (MAB) from three patients with APS and two healthy controls. We then compared the antigen binding patterns and the heavy chain variable region (VH) DNA sequences of the MAB derived from patients with APS to those from healthy controls. The results of this study indicate that APLA and AECA comprise a highly heterogeneous population of antibodies with respect to the antigens they recognize, as well as VHgene usage. MAB derived from patients with APS do not differ from those derived from normal individuals based on either antigen recognition or VHgene usage. These results suggest the importance of additional predisposing factors in the pathogenesis of APS.
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Details
- Title
- Heterogeneity of Anti-Phospholipid and Anti-Endothelial Cell Antibodies
- Creators
- Hua Shan - University of PennsylvaniaJune Goldman - University of PennsylvaniaGina Cunto - University of PennsylvaniaJoseph Manuppello - University of PennsylvaniaIrwin Chaiken - University of PennsylvaniaDouglas B Cines - University of PennsylvaniaLeslie E Silberstein - University of Pennsylvania
- Publication Details
- Journal of autoimmunity, v 11(6), pp 651-660
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology; Drexel University
- Web of Science ID
- WOS:000077920500008
- Scopus ID
- 2-s2.0-0032413627
- Other Identifier
- 991019520425304721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Immunology