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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Heterogeneity of Informant-Reported Functional Performance in Mild Cognitive Impairment: A Latent Profile Analysis of the Functional Activities Questionnaire
Journal of Alzheimer's disease, v 68(4), pp 1611-1624
01 Jan 2019
PMID: 30909219
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Heterogeneity of subtle functional difficulties in mild cognitive impairment (MCI) remains poorly understood. We characterized patterns of informant reports of functional abilities among participants with MCI and the relation between functional ability pattern and cognitive abilities and subsequent decline. Data from 4,273 MCI participants from the National Alzheimer's Coordinating Center (NACC) Uniform Data Set (UDS) were included in latent profile analyses (LPA) of informant responses on the Functional Activities Questionnaire (FAQ). Profiles from the best fitting model were compared on demographic, clinical, and cognitive variables. The best fitting model supported three profiles varying by level and type of difficulty: intact function (n = 3,299), intermediate (n = 769), and high ratings of difficulty (n = 205). For the Intermediate profile, items related to finances, remembering dates, and travel were rated as most difficult. The High Ratings profile also had elevated ratings on the meal preparation item. Participants with either the Intermediate or High Ratings profile demonstrated a three-fold increase in conversion to dementia as compared to participants with the Intact profile. Demographically, the Intact profile was younger and consisted of a higher proportion of minorities. On cognitive tests, the Intact profile showed the best performance, and the Intermediate profile performed comparably to or better than the High Ratings profile. There is meaningful heterogeneity in informant ratings of function in MCI, though individuals with MCI whose informants report even intermediate-level functional difficulties are more likely to progress to dementia, suggesting that even subtle functional difficulties place individuals at higher risk for future decline.
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- Title
- Heterogeneity of Informant-Reported Functional Performance in Mild Cognitive Impairment: A Latent Profile Analysis of the Functional Activities Questionnaire
- Creators
- Rachel Mis - Temple UniversityKathryn Devlin - Thomas Jefferson UniversityDeborah Drabick - Temple UniversityTania Giovannetti - Temple University
- Publication Details
- Journal of Alzheimer's disease, v 68(4), pp 1611-1624
- Publisher
- Ios Press
- Number of pages
- 14
- Grant note
- U01 AG016976 / NIA/NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) P30AG019610; P30 AG013846; P50 AG008702; P50 AG025688; P50 AG047266; P30 AG010133; P50 AG005146; P50 AG005134; P50 AG016574; P50 AG005138; P30 AG008051 / NIA; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000465612500025
- Scopus ID
- 2-s2.0-85064862425
- Other Identifier
- 991021463425204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences