Journal article
Heterogeneity of changes in lymphoproliferative ability with increasing age
Experimental gerontology, v 26(2)
1991
PMID: 1915696
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Although mean mitogen-induced lymphoproliferation decreases with increased age, the response of individual subjects demonstrates great heterogeneity. Results of this study clearly illustrate that individual variation is apparent not only in the level of proliferation, but also in the amount of interleukin-2 (IL-2) detectable after mitogen stimulation. Further, addition of exogenous IL-2 significantly increases proliferation in only about one third of elderly subjects. Data from inbred strains of rats housed under identical environmental conditions indicate that although genetic factors greatly influence both the level of proliferation and the rate of decline with age, variation occurs even within one inbred strain of rat.
Metrics
Details
- Title
- Heterogeneity of changes in lymphoproliferative ability with increasing age
- Creators
- Donna M. Murasko - Drexel UniversityBarbara J. Nelson - Drexel UniversityDeborah Matour - Drexel UniversityI.Michael Goonewardene - Drexel UniversityDonald Kaye - Drexel University
- Publication Details
- Experimental gerontology, v 26(2)
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology; Medicine (Graduate)
- Web of Science ID
- WOS:A1991FR68700020
- Scopus ID
- 2-s2.0-0025766992
- Other Identifier
- 991019184209004721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Geriatrics & Gerontology