Journal article
Heterogeneous response of cerebral blood flow to hypotension demonstrated by laser speckle imaging flowmetry in rats
Neuroscience letters, v 368(2), pp 151-156
2004
PMID: 15351439
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The response of cerebral blood flow (CBF) to mild hypotension shows great variability. CBF changes in different cortical regions at a mean arterial blood pressure (MABP) of 70
mmHg (near the lower limit of CBF-pressure autoregulation) were analyzed using laser speckle imaging flowmetry (LSIF). We hypothesize that variations in CBF autoregulation might be due to differences between regions within the cortex of each animal, regional heterogeneity, as opposed to differences between animals. Different responses of local CBF to hypotension in each rat were demonstrated as %CBF
70, the ratio of CBF at a MABP of 70
mmHg to CBF at a MABP of 100
mmHg. Regional heterogeneity ranged from 12 to 51%, expressed as the coefficient of variation of %CBF
70. At the same time LSIF revealed distinctly different patterns of CBF-pressure autoregulation between animals. Between-animal heterogeneity represents a continuous distribution, spread between animals with predominantly decreased CBF (%CBF
70 < 85%, rat #3) and animals with a high proportion of increased flow responses (%CBF
70 > 115%, rat #2). There are approximately equal contributions to the heterogeneity of %CBF
70 from within-animal (57 ± 5%, percent variance ± standard error) and between-animal (43 ± 26%) variations. Within-animal variations could be due to heterogeneity of vascular anatomy, while the diversity of vascular control mechanisms might contribute to between-animal variations.
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Details
- Title
- Heterogeneous response of cerebral blood flow to hypotension demonstrated by laser speckle imaging flowmetry in rats
- Creators
- Alexander Kharlamov - Department of Anesthesiology, Allegheny General Hospital, Drexel University College of Medicine, 320 East North Avenue, Pittsburgh, PA 15212, USA.Benjamin R. Brown - Department of Anesthesiology, Allegheny General Hospital, Drexel University College of Medicine, 320 East North Avenue, Pittsburgh, PA 15212, USA.Kirk A. Easley - Emory UniversityStephen C. Jones - Drexel University
- Publication Details
- Neuroscience letters, v 368(2), pp 151-156
- Publisher
- Elsevier Ireland Ltd
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Anesthesiology and Perioperative Medicine
- Web of Science ID
- WOS:000223967800008
- Scopus ID
- 2-s2.0-4444339339
- Other Identifier
- 991019167712104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences