Journal article
Hierarchically ordered polymer nanofiber shish kebabs as a bone scaffold material
Journal of biomedical materials research. Part A, v 105(6), pp 1786-1798
01 Jun 2017
PMID: 28198135
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The ideal bone scaffold harnesses the body's ability to regenerate bone in critical size defects. A potential strategy to design the ideal bone scaffold is to mimic the natural structure of bone at the molecular level. The orientation and spatial distribution of nanocrystals in the organic matrix are two important and distinctive structural characteristics associated with natural bone. There has yet to be a synthetic system or scaffold that is able to control both the spatial distribution and orientation of the hydroxyapatite crystalline structure. To mimic the unique hybrid structure of natural bone using synthetic materials, there have been a number of reported approaches to control the mineral nanocrystal orientation on synthetic scaffolds. However, the spatial distribution of minerals is challenging to reproduce in a biomimetic manner. Herein we report using block copolymer-decorated polymer nanofibers to achieve biomineralized fibrils with precise control of both mineral crystal orientation and spatial distribution. We show that the crystallization of poly(caprolactone)-b-poly(acrylic acid) block copolymer on poly(caprolactone) nanofibers resulted in a unique shish kebab structure that significantly enhances the mechanical properties of the nanofibers, and is cytocompatible to L-929 mouse fibroblast cells. (c) 2017 Wiley Periodicals, Inc.
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Details
- Title
- Hierarchically ordered polymer nanofiber shish kebabs as a bone scaffold material
- Creators
- Xi Chen - Drexel UniversitySarah E. Gleeson - Department of Materials Science and EngineeringDrexel UniversityPhiladelphia Pennsylvania19104Tony Yu - Department of Materials Science and EngineeringDrexel UniversityPhiladelphia Pennsylvania19104Nasreen Khan - Department of Materials Science and EngineeringDrexel UniversityPhiladelphia Pennsylvania19104Robert W. Yucha - Department of Materials Science and EngineeringDrexel UniversityPhiladelphia Pennsylvania19104Michele Marcolongo - Department of Materials Science and EngineeringDrexel UniversityPhiladelphia Pennsylvania19104Christopher Y. Li - Department of Materials Science and EngineeringDrexel UniversityPhiladelphia Pennsylvania19104
- Publication Details
- Journal of biomedical materials research. Part A, v 105(6), pp 1786-1798
- Publisher
- Wiley
- Number of pages
- 13
- Grant note
- 1507760 / Direct For Mathematical & Physical Scien; National Science Foundation (NSF); NSF - Directorate for Mathematical & Physical Sciences (MPS) Drexel DARE grant MRI-1040166 / grant NSF DMR-1507760 / National Science Foundation grant; National Science Foundation (NSF)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Materials Science and Engineering
- Web of Science ID
- WOS:000400329500023
- Scopus ID
- 2-s2.0-85017462230
- Other Identifier
- 991019167582504721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials