Journal article
High-Density Lipoprotein Particles and Markers of Inflammation and Thrombotic Activity in Patients with Untreated HIV Infection
The Journal of infectious diseases, v 201(2)
15 Jan 2010
PMID: 19954384
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background. Untreated human immunodeficiency virus (HIV) infection is associated with changes in blood lipids, inflammation, thrombotic activity, and increased risk for cardiovascular disease.
Methods. We studied high-density lipoprotein particle (HDLp) concentrations and inflammatory (high-sensitivity C-reactive protein [hsCRP] and interleukin [IL] 6), endothelial activation (E-selectin and soluble intercellular adhesion molecule-1 [sICAM-1]), and thrombotic (fibrinogen and D-dimer) biomarkers in a group of 32 untreated HIV-infected and 29 uninfected persons. Differences in the levels of blood lipids and biomarkers by HIV status were examined before and after adjustment for age, sex, race/ethnicity, smoking status, body mass index, and the presence of hepatitis C.
Results. HIV-infected participants, compared with uninfected participants, had lower HDL cholesterol (HDLc) levels (-26%) and HDLp numbers (-21%), with reductions in large (-50%) and small (-20%) HDLp, specifically P <=.01 for all). A trend was present for higher total cholesterol (P=.15) and triglyceride levels (P=.11) among individuals with HIV infection. Levels of IL-6, sICAM-1, and D-dimer were 65%-70% higher in HIV-infected participants (P <=.02 for all). Covariate adjustment did not diminish these associations. For HIV-infected participants, total and small HDLp (respectively) tended to correlate inversely with levels of IL-6 (P=.08 and P=.02), sICAM-1 (P<.01 for both) and D-dimer (P=.03 and P<.01).
Conclusions. Persons with untreated HIV infection have lower HDLp (primarily large and small HDLp) and higher IL-6, sICAM-1, and D-dimer levels, and the relationship of these markers to HIV-mediated atherosclerotic risk requires further study.
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Details
- Title
- High-Density Lipoprotein Particles and Markers of Inflammation and Thrombotic Activity in Patients with Untreated HIV Infection
- Creators
- Jason Baker - University of MinnesotaWoubeshet Ayenew - University of MinnesotaHarrison Quick - University of MinnesotaKatherine Huppler Hullsiek - University of MinnesotaRussell Tracy - University of VermontKeith Henry - University of MinnesotaDaniel Duprez - University of MinnesotaJames D. Neaton - University of Minnesota
- Publication Details
- The Journal of infectious diseases, v 201(2)
- Publisher
- Oxford Univ Press
- Number of pages
- 8
- Grant note
- 5 T32 GM12453-03 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA K12RR023247 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) F32GM012453 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000273051200015
- Scopus ID
- 2-s2.0-75649105079
- Other Identifier
- 991020100203804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology
- Infectious Diseases
- Microbiology