Journal article
High-Frequency Audiometric Monitoring for Early Detection of Aminoglycoside Ototoxicity
The Journal of infectious diseases, Vol.165(6), pp.1026-1032
01 Jun 1992
PMID: 1583319
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Treatment with aminoglycosidesis known to cause irreversible hearing loss, typically affecting higher-frequency hearing first and progressing to lower frequencies. Standardized methodology has not been developed for early detection of ototoxicity. Serial conventional (0.25–8 kHz) and high-frequency (9–20 kHz) hearing threshold monitoring was done prospectivelyin 53 hospitalized patients administered aminoglycosides. Hearing loss occurred in 47% of the ears studied, with hearing loss first appearing in the high-frequency range in 71% of ears showing change. Analysis of data on an individual basis revealed a five-frequency range most susceptible to initial ototoxicity. Testing only this range would have resulted in early identification of 82% of ears showing change. Results confirm the critical need for serial auditory threshold monitoring encompassing high frequencies in patients receiving aminoglycosides.A shortened five-frequency monitoring protocol is presented and suggested for use with patients unable to tolerate lengthy audiometric testing procedures.
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Details
- Title
- High-Frequency Audiometric Monitoring for Early Detection of Aminoglycoside Ototoxicity
- Creators
- Stephen A. Fausti - Portland VA Medical CenterJames A. Henry - Auditory Research Laboratory and Department of Audiology, VA Medical Center, Portland, OregonHeidi I. Schaffer - Oregon Health & Science UniversityDeanna J. Olson - Oregon Health & Science UniversityRichard H. Frey - Oregon Health & Science UniversityWalter J. McDonald - Oregon Health & Science University
- Publication Details
- The Journal of infectious diseases, Vol.165(6), pp.1026-1032
- Publisher
- The University of Chicago Press
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Audiology - Distance
- Web of Science ID
- WOS:A1992HV96000007
- Scopus ID
- 2-s2.0-0026590124
- Other Identifier
- 991022058596804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology
- Infectious Diseases
- Microbiology