Journal article
High-Frequency Monitoring for Early Detection of Cisplatin Ototoxicity
Archives of otolaryngology--head & neck surgery, Vol.119(6), pp.661-666
01 Jun 1993
PMID: 8499098
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cisplatin can cause irreversible hearing loss initially detectable as impairment of high-frequency hearing with progression to lower frequencies. Many patients receiving cisplatin are too ill to tolerate lengthy audiometric testing. Therefore, a rapid and sensitive high-frequency monitoring strategy to detect cisplatin-induced ototoxicity is needed. Serial conventional (0.25 to 8 kHz) and high-frequency (≥8 kHz) threshold monitoring was performed in patients receiving cisplatin, resulting in 84% of ears showing hearing loss, of which 71% were detected first in frequencies of 8 kHz or greater. By analysis according to an individualized, specific high-frequency range, early identification of hearing loss occurred in 94% of ears showing change. This five-frequency procedure is a sensitive detector of ototoxicity and is proposed as an alternative monitoring protocol for patients receiving cisplatin who cannot tolerate extended testing.(Arch Otolaryngol Head Neck Surg. 1993;119:661-666)
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Details
- Title
- High-Frequency Monitoring for Early Detection of Cisplatin Ototoxicity
- Creators
- Stephen A Fausti - Portland VA Medical CenterJames A Henry - Portland VA Medical CenterHeidi I Schaffer - Oregon Health & Science UniversityDeanna J Olson - Oregon Health & Science UniversityRichard H Frey - Portland VA Medical CenterGrover C Bagby - Portland VA Medical Center
- Publication Details
- Archives of otolaryngology--head & neck surgery, Vol.119(6), pp.661-666
- Publisher
- American Medical Association
- Number of pages
- 6
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Audiology - Distance
- Web of Science ID
- WOS:A1993LF78300014
- Scopus ID
- 2-s2.0-0027208868
- Other Identifier
- 991022057790504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Otorhinolaryngology
- Surgery