Journal article
High-dose-rate interstitial computed tomography–based brachytherapy for the treatment of cervical cancer: Early results
Brachytherapy, v 11(5), pp 408-412
01 Sep 2012
PMID: 22513106
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
There is limited published data on high-dose-rate interstitial brachytherapy (HDRBT) for cervical cancer resulting in no consensus on a fractionation schedule. This study reports our experience of CT-based HDRBT for treating locally advanced cervical cancer.
Forty-seven patients diagnosed with Stage IIB–IVA cervical cancer not suitable for intracavitary brachytherapy were treated with HDRBT from March 2005 to November 2010. All patients received external beam radiation therapy with a median dose of 45Gy and all had one interstitial implantation followed by 3.75–5Gy×5 fractions in a twice daily (BID) schedule. Total doses for clinical target volume and organs at risk, including rectum, bladder, and sigmoid, were summated and normalized to a biologically equivalent dose of 2Gy per fraction. At 3 months posttherapy, early response was assessed with clinical examination and positron emission tomography (PET/CT) imaging.
Median clinical target volume D90 (dose delivered to 90% of the clinical target volume) was 76.3 (59.0–86.9) Gy and the 2cc dose to the bladder, rectum, and sigmoid colon organs were 70.2 (55.9–77.7), 65.8 (54.9–80.6), and 56.5 (45.0–71.2) Gy, respectively. Posttreatment, 12 patients had evidence of persistent disease on PET/CT. Eleven of the 35 patients who had complete response developed recurrences. Two patients developed late Radiation Therapy Oncology Group ≥3 rectal toxicities. Two-year actuarial local control, disease-free survival, overall survival, and Grade ≥3 toxicities were 61%, 43%, 59%, and 10%, respectively.
Our approach of a single implantation procedure followed by five fractions of HDRBT was well tolerated with early results demonstrating a moderate response and local control rate with acceptable toxicities.
Metrics
Details
- Title
- High-dose-rate interstitial computed tomography–based brachytherapy for the treatment of cervical cancer: Early results
- Creators
- Neeta Kannan - UPMC Hillman Cancer CenterSushil Beriwal - UPMC Hillman Cancer CenterHayeon Kim - UPMC Hillman Cancer CenterChristopher Houser - UPMC Hillman Cancer CenterRobert Mogus - UPMC Hillman Cancer CenterPaniti Sukumvanich - Magee-Womens HospitalAlexander B. Olawaiye - Magee-Womens HospitalScott Richard - Magee-Womens HospitalJoseph L. Kelley - Magee-Womens HospitalRobert P. Edwards - Magee-Womens HospitalThomas C. Krivak - Magee-Womens Hospital
- Publication Details
- Brachytherapy, v 11(5), pp 408-412
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine); Obstetrics and Gynecology
- Web of Science ID
- WOS:000308626400014
- Scopus ID
- 2-s2.0-84865355678
- Other Identifier
- 991021897366704721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Oncology
- Radiology, Nuclear Medicine & Medical Imaging