Journal article
High field gradient targeting of magnetic nanoparticle-loaded endothelial cells to the surfaces of steel stents
Proceedings of the National Academy of Sciences - PNAS, v 105(2), pp 698-703
15 Jan 2008
PMID: 18182491
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A cell delivery strategy was investigated that was hypothesized to enable magnetic targeting of endothelial cells to the steel surfaces of intraarterial stents because of the following mechanisms: (
i
) preloading cells with biodegradable polymeric superparamagnetic nanoparticles (MNPs), thereby rendering the cells magnetically responsive; and (
ii
) the induction of both magnetic field gradients around the wires of a steel stent and magnetic moments within MNPs because of a uniform external magnetic field, thereby targeting MNP-laden cells to the stent wires.
In vitro
studies demonstrated that MNP-loaded bovine aortic endothelial cells (BAECs) could be magnetically targeted to steel stent wires.
In vivo
MNP-loaded BAECs transduced with adenoviruses expressing luciferase (Luc) were targeted to stents deployed in rat carotid arteries in the presence of a uniform magnetic field with significantly greater Luc expression, detected by
in vivo
optical imaging, than nonmagnetic controls.
Metrics
Details
- Title
- High field gradient targeting of magnetic nanoparticle-loaded endothelial cells to the surfaces of steel stents
- Creators
- Boris Polyak - Department of Surgery, Drexel University College of Medicine, Philadelphia, PA 19102Ilia Fishbein - Division of Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA 19104Michael Chorny - Division of Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA 19104Ivan Alferiev - Division of Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA 19104Darryl Williams - Division of Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA 19104Ben Yellen - Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708; andGary Friedman - Department of Electrical and Computer Engineering, Drexel University, Philadelphia, PA 19104Robert J Levy - Division of Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA 19104
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, v 105(2), pp 698-703
- Publisher
- National Academy of Sciences
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Electrical and Computer Engineering; Surgery
- Web of Science ID
- WOS:000252551100055
- Scopus ID
- 2-s2.0-38649115312
- Other Identifier
- 991014877717504721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems