Journal article
High-frequency oscillations (>200 Hz) in the human non-parkinsonian subthalamic nucleus
Brain research bulletin, v 74(1)
2007
PMID: 17683793
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The human basal ganglia, and in particular the subthalamic nucleus (STN), can oscillate at surprisingly high frequencies, around 300
Hz [G. Foffani, A. Priori, M. Egidi, P. Rampini, F. Tamma, E. Caputo, K.A. Moxon, S. Cerutti, S. Barbieri, 300-Hz subthalamic oscillations in Parkinson's disease, Brain 126 (2003) 2153–2163]. It has been proposed that these oscillations could contribute to the mechanisms of action of deep brain stimulation (DBS) [G. Foffani, A. Priori, Deep brain stimulation in Parkinson's disease can mimic the 300
Hz subthalamic rhythm, Brain 129 (2006) E59]. However, the physiological role of high-frequency STN oscillations is questionable, because they have been observed only in patients with advanced Parkinson's disease and could therefore be secondary to the dopamine-depleted parkinsonian state. Here, we report high-frequency STN oscillations in the range of the 300-Hz rhythm during intraoperative microrecordings for DBS in an awake patient with focal dystonia as well as in a patient with essential tremor (ET). High-frequency STN oscillations are therefore not exclusively related to parkinsonian pathophysiology, but may represent a broader feature of human STN function.
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Details
- Title
- High-frequency oscillations (>200 Hz) in the human non-parkinsonian subthalamic nucleus
- Creators
- S.F. Danish - University of PennsylvaniaJ.T. Moyer - University of PennsylvaniaL.H. Finkel - University of PennsylvaniaG.H. Baltuch - University of PennsylvaniaJ.L. Jaggi - University of PennsylvaniaA. Priori - Ospedale MaggioreG. Foffani - Drexel University
- Publication Details
- Brain research bulletin, v 74(1)
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000249231300011
- Scopus ID
- 2-s2.0-34547561092
- Other Identifier
- 991019353630604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences