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Journal article
High frequency repetitive Transcranial Magnetic Stimulation promotes long lasting phrenic motoneuron excitability via GABAergic networks
Respiratory physiology & neurobiology, v 292, 103704
Oct 2021
PMID: 34058433
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
•Acute high frequency rTMS increases spinal motoneurons excitability.•Its effect is modulated by the GABAergic system.•The treated population is divided in “Responder” and “Non-responder” subpopulations.
Repetitive transcranial magnetic stimulation (rTMS) is a promising, innovative, and non-invasive therapy used clinically. Efficacy of rTMS has been demonstrated to ameliorate psychiatric disorders and neuropathic pain through neuromodulation of affected neural circuits. However, little is known about the mechanisms and the specific neural circuits via which rTMS facilitates these functional effects. The aim of this study was to begin revealing the mechanisms by which rTMS may tap into existing neural circuits, by using a well characterized spinal motor circuit – the phrenic circuit. Here we hypothesized that rTMS can be used to enhance phrenic motoneuron excitability in anesthetized Sprague Dawley rats. Multiple acute rTMS protocols were used revealing 10 Hz rTMS protocol induced a robust, long-lasting increase in phrenic motoneuron excitability, functionally evaluated by diaphragm motor evoked potentials (59.1 ± 21.1 % of increase compared to baseline 60 min after 10 Hz protocol against 6.0 ± 5.8 % (p = 0.007) for Time Control, -5.8 ± 7.4 % (p < 0.001) for 3 Hz, and 5.2 ± 12.5 % (p = 0.008) for 30 Hz protocols). A deeper analyze allowed to discriminate “responder” and “non-responder” subgroups among 10 Hz rTMS treated animals. Intravenous injections of GABAA and GABAB receptor agonists prior to 10 Hz rTMS treatment, abolished the enhanced phrenic motoneuron excitability, suggesting GABAergic input plays a mechanistic role in rTMS-induced phrenic excitability. These data demonstrate that a single high frequency rTMS protocol at 10 Hz increases phrenic motoneuron excitability, mediated by a local GABAergic “disinhibition”. By understanding how rTMS can be used to affect neural circuits non-invasively we can begin to harness the therapeutic potential of this neuromodulatory strategy to promote recovery after disease or injury to the central nervous system.
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Details
- Title
- High frequency repetitive Transcranial Magnetic Stimulation promotes long lasting phrenic motoneuron excitability via GABAergic networks
- Creators
- Pauline Michel-Flutot - University of Paris-SaclayLyandysha V. Zholudeva - Gladstone InstitutesMargo L. Randelman - Drexel UniversityTherese B. Deramaudt - University of Paris-SaclayArnaud Mansart - University of Paris-SaclayJean-Claude Alvarez - University of Paris-SaclayKun-Ze Lee - National Sun Yat-sen UniversityMichel Petitjean - Université Paris-Saclay CIAMS, 91405, Orsay, France; CIAMS, Université d'Orléans, 45067, Orléans, France; Service d'Explorations Fonctionnelles bi-site, Hôpital Antoine Béclère, 92140, Clamart, France.Marcel Bonay - University of Paris-SaclayMichael A. Lane - Drexel UniversityStéphane Vinit - University of Paris-Saclay
- Publication Details
- Respiratory physiology & neurobiology, v 292, 103704
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000678426300003
- Scopus ID
- 2-s2.0-85107143318
- Other Identifier
- 991019168737304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Physiology
- Respiratory System