Journal article
Higher serum uric acid is associated with body fat, retinol-binding protein 4, and antioxidative status in Brazilian children
NUTRITION, v 113, 112079
Sep 2023
PMID: 37354651
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective: The aim of this study was to evaluate the association of serum uric acid (SUA) with adiposity, adi-pokines, and anti-and oxidative markers in Brazilian children.Methods: This was a cross-sectional investigation with 378 children ages 8 to 9 yin Vi,cosa, Minas Gerais, Bra-zil. Information on sociodemographic and lifestyle characteristics was obtained via questionnaires, and body fat was determined by dual energy x-ray absorptiometry. We compared the distributions of adiposity (total and central), adipokines (adiponectin, chemerin, leptin, and retinol-binding protein 4 [RBP4]), anti-and oxi-dative markers (plasma ferric reducing antioxidant power [FRAP], superoxide dismutase [SOD], and malon-dialdehyde [MDA]) by SUA categories using linear regression.Results: SUA was positively associated with total and central fat. Every standard deviation (SD) of SUA was related, respectively, to a 3.4 (95% confidence interval [CI], 2.4-4.4), 4 (95% CI, 2.8-5.1), 4.2 (95% CI, 2.9-5.5), and 3.5 (95% CI, 2.4-4.6) units higher of total, truncal, android, and gynoid fat. We found a positive associa-tion of SUA with RBP4 and FRAP, and a negative association with MDA. Every SD of SUA was related, respec-tively, to 0.1 (95% CI, 0.01-0.1) and 7.8 (95% CI, 5.5-10.1) units higher of RBP4 and FRAP; and to-0.3 (95% CI,-0.5 to-0.1) units lower of MDA.Conclusions: SUA was positively associated with adiposity, RBP4, and antioxidative status in Brazilian chil-dren.& COPY; 2023 Elsevier Inc. All rights reserved.
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Details
- Title
- Higher serum uric acid is associated with body fat, retinol-binding protein 4, and antioxidative status in Brazilian children
- Publication Details
- NUTRITION, v 113, 112079
- Publisher
- ELSEVIER SCIENCE INC; NEW YORK
- Grant note
- Financial support for this study was received from the Fundacao de Amparo a & nbsp;Pesquisa do Estado de Minas Gerais (FAPEMIG; grant number CDS-APQ-02979-16), the Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq; grant numbers 407547/2012-6 and 478910/2013-4), and the Coordenacao de Aperfeicoamento de Nivel Superior - Brasil (CAPES; code 001).
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:001055034300001
- Scopus ID
- 2-s2.0-85162261209
- Other Identifier
- 991021861298804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Nutrition & Dietetics