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Highly stretchable gelatin‐polyacrylamide hydrogel for potential transdermal drug release
Journal article   Open access   Peer reviewed

Highly stretchable gelatin‐polyacrylamide hydrogel for potential transdermal drug release

Zhen Qiao, Long Tran, Jesse Parks, Yao Zhao, Nan Hai, Yinghui Zhong and Hai‐Feng Ji
Nano select, v 2(1), pp 107-115
Jan 2021
DOI: https://doi.org/10.1002/nano.202000087
url
https://doi.org/10.5824/1309-1581.2018.3.001.xView
Published, Version of Record (VoR) Open
url
https://doi.org/10.1002/nano.202000087View
Published, Version of Record (VoR) Open

Abstract

chemical crosslinking drug delivery highly stretchable hydrogel physical crosslinking polyacrylamide tough
Stretchable hydrogels have been used for a number of biomedical applications. This research focused on the study of a highly stretchable and tough hydrogel made of gelatin and polyacrylamide towards transdermal drug delivery applications. Four drug compounds, nicotine, lidocaine hydrochloride, diltiazem hydrochloride and diclofenac sodium, were used for the evaluation. The release rates of these compounds follow an order: lidocaine > diltiazem > nicotine > diclofenac, which showed a strong correlation between the release rate with their solubility in water at pH 5.5. The kinetics study showed a linear and sustainable release of all tested drugs in the first 8 hours. Experiments were conducted in vitro on replicated human skin. Cytotoxicity studies indicate hydrogel is nontoxic to human cells. The highly stretchable and tough characters of the hydrogel the strength of the hydrogel reduce the severity of wear and tear issues over time for transdermal drug release. This research focused on the study of a highly stretchable and tough hydrogel made of gelatin and polyacrylamide towards transdermal drug delivery applications. The release rates of these compounds follow an order: lidocaine>diltiazem>nicotine>diclofenac, which showed a strong correlation between the release rate with their solubility in water at pH 5.5 and their interactions with the gel network.

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