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Journal article
Hindlimb Somatosensory Information Influences Trunk Sensory and Motor Cortices to Support Trunk Stabilization
Cerebral cortex (New York, N.Y. 1991), v 31(11), pp 5165-5187
01 Nov 2021
PMID: 34165153
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Sensorimotor integration in the trunk system is poorly understood despite its importance for functional recovery after neurological injury. To address this, a series of mapping studies were performed in the rat. First, the receptive fields (RFs) of cells recorded from thoracic dorsal root ganglia were identified. Second, the RFs of cells recorded from trunk primary sensory cortex (S1) were used to assess the extent and internal organization of trunk S1. Finally, the trunk motor cortex (M1) was mapped using intracortical microstimulation to assess coactivation of trunk muscles with hindlimb and forelimb muscles, and integration with S1. Projections from trunk S1 to trunk M1 were not anatomically organized, with relatively weak sensorimotor integration between trunk S1 and M1 compared to extensive integration between hindlimb S1/M1 and trunk M1. Assessment of response latency and anatomical tracing suggest that trunk M1 is abundantly guided by hindlimb somatosensory information that is derived primarily from the thalamus. Finally, neural recordings from awake animals during unexpected postural perturbations support sensorimotor integration between hindlimb S1 and trunk M1, providing insight into the role of the trunk system in postural control that is useful when studying recovery after injury.
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Details
- Title
- Hindlimb Somatosensory Information Influences Trunk Sensory and Motor Cortices to Support Trunk Stabilization
- Creators
- Bharadwaj Nandakumar - Drexel UniversityGary H. Blumenthal - Drexel UniversityFrancois Philippe Pauzin - University of California, DavisKaren A. Moxon - Drexel University
- Publication Details
- Cerebral cortex (New York, N.Y. 1991), v 31(11), pp 5165-5187
- Publisher
- Oxford Univ Press
- Number of pages
- 23
- Grant note
- 1933751 / National Science Foundation; National Science Foundation (NSF) R01NS096971 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000708798900024
- Scopus ID
- 2-s2.0-85118096561
- Other Identifier
- 991019168382104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences