Journal article
Hippocampal and cortical high-frequency oscillations orchestrate human semantic networks during word list memory
iScience, v 28(4), 112171
18 Apr 2025
PMID: 40235588
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Episodic memory requires the precise coordination between the hippocampus and distributed cortical regions. This may be facilitated by bursts of brain activity called high-frequency oscillations (HFOs). We hypothesized that HFOs activate specific networks during memory retrieval and aimed to describe the electrophysiological properties of HFO-associated activity. To study this, we recorded intracranial electroencephalography while human participants performed a list learning task. Hippocampal HFOs (hHFOs) increased during encoding and retrieval, and these increases correlated with memory performance. During retrieval, hHFOs demonstrated activation of semantic processing regions that were previously active during encoding. This consisted of broadband high-frequency activity (HFA) and cortical HFOs. HFOs in the anterior temporal lobe, a major semantic hub, co-occurred with hHFOs, particularly during retrieval. These coincident HFOs were associated with greater cortical HFA and cortical theta bursts. Hence, HFOs may support synchronization of activity across distributed nodes of the hippocampal-cortical memory network.
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Details
- Title
- Hippocampal and cortical high-frequency oscillations orchestrate human semantic networks during word list memory
- Creators
- Akash Mishra - Hofstra UniversitySerdar Akkol - Northwell HealthElizabeth Espinal - Drexel UniversityNoah Markowitz - Feinstein Institute for Medical ResearchGelana Tostaeva - Feinstein Institute for Medical ResearchElisabeth Freund - Northwell HealthAshesh D. Mehta - Hofstra UniversityStephan Bickel (Corresponding Author) - Nathan Kline Institute for Psychiatric Research
- Publication Details
- iScience, v 28(4), 112171
- Publisher
- Elsevier
- Grant note
- F30MH139332 / National Institutes of Health (100000002) National Institute of Mental Health (http://data.elsevier.com/vocabulary/SciValFunders/100000025) R01DC019979 / National Institutes of Health (100000002) R01DC019979; F30MH139332 / National Institutes of Health (http://data.elsevier.com/vocabulary/SciValFunders/100000002) National Institute on Deafness and Other Communication Disorders (100000055) National Institutes of Health (http://data.elsevier.com/vocabulary/SciValFunders/100000002) National Institute of Mental Health (100000025) National Institute on Deafness and Other Communication Disorders (http://data.elsevier.com/vocabulary/SciValFunders/100000055)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:001460465500001
- Scopus ID
- 2-s2.0-105001327616
- Other Identifier
- 991022197398804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences