Journal article
Hippocampal efferents to retrosplenial cortex and lateral septum are required for memory acquisition
Learning & memory (Cold Spring Harbor, N.Y.), v 27(8), pp 310-318
01 Aug 2020
PMID: 32669386
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Learning and memory involves a large neural network of many brain regions, including the notable hippocampus along with the retrosplenial cortex (RSC) and lateral septum (LS). Previous studies have established that the dorsal hippocampus (dHPC) plays a critical role during the acquisition and retrieval/expression of episodic memories. However, the role of downstream circuitry from the dHPC, including the dHPC-to-RSC and dHPC-to-LS pathways, has come under scrutiny only recently. Here, we used an optogenetic approach with contextual fear conditioning in mice to determine whether the above two pathways are involved in acquisition and expression of contextual fear memory. We found that a selective inhibition of the dHPC neuronal terminals in either the RSC or LS during acquisition impaired subsequent memory performance, suggesting that both the dHPC-to-RSC and dHPC-to-LS pathways play a critical role in memory acquisition. We also selectively inhibited the two dHPC efferent pathways during memory retrieval and found a differential effect on memory performance. These results indicate the intricacies of memory processing and that hippocampal efferents to cortical and subcortical regions may be differentially involved in aspects of physiological and cognitive memory processes.
Metrics
Details
- Title
- Hippocampal efferents to retrosplenial cortex and lateral septum are required for memory acquisition
- Creators
- Ashley N. Opalka - Drexel UniversityDong V. Wang - Drexel University
- Publication Details
- Learning & memory (Cold Spring Harbor, N.Y.), v 27(8), pp 310-318
- Publisher
- Cold Spring Harbor Laboratory Press
- Grant note
- R01 MH119102 / ;
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy; Neurology
- Web of Science ID
- WOS:000562020800003
- Scopus ID
- 2-s2.0-85088156199
- Other Identifier
- 991020100083104721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Neurosciences
- Psychology, Experimental