Journal article
Histamine and serotonin independently elicit drinking in the rat
Physiology & behavior, v 34(6), pp 963-967
Jun 1985
PMID: 4059386
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Drinking elicited by SC histamine or serotonin (5-HT) was studied in Sprague-Dawley male rats following 0.9% NaCl or combined antagonism of H1 and H2 histamine receptors using dexbrompheniramine (DXB) and cimetidine (C), or following antagonism of 5-HT receptors using methysergide (M). Histaminergic antagonism using IP 1 mg/kg DXB plus 16 mg/kg C abolished drinking elicited by SC 2.5 mg/kg histamine, but it failed to inhibit drinking elicited by the ED50 or by the ED100 for SC 5-HT in the same rats. Serotonergic antagonism using IP 3 mg/kg M abolished drinking elicited by SC 0.63 mg/kg 5-HT, but it failed to inhibit drinking elicited by the ED50 or by the ED100 for SC histamine in the same rats. These findings demonstrate that activation of peripheral 5-HT receptors is not necessary for SC histamine to elicit drinking and that activation of peripheral histamine receptors is not necessary for SC 5-HT to elicit drinking. This demonstrates that histamine and 5-HT activate different receptors to elicit drinking in the rat. The finding that the ED50 for histamine and the ED50 for 5-HT are not additive in their effects on drinking is consistent with the notion that a single mechanism mediates the dipsogenic effects of SC histamine and SC 5-HT in the rat.
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Details
- Title
- Histamine and serotonin independently elicit drinking in the rat
- Creators
- F. Scott Kraly - Department of Psychology, Colgate University, Hamilton, NY 13346 USAKenny J. Simansky - Drexel UniversityLisa A. Coogan - Drexel UniversityMarsha S. Trattner - Drexel University
- Publication Details
- Physiology & behavior, v 34(6), pp 963-967
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:A1985APK6100018
- Scopus ID
- 2-s2.0-0022411170
- Other Identifier
- 991019184303404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Behavioral Sciences
- Psychology, Biological