Journal article
Histamine receptor H1 is required for TCR-mediated p38 MAPK activation and optimal IFN-γ production in mice
The Journal of clinical investigation, v 117(11), pp 3507-3518
01 Nov 2007
PMID: 17965772
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Histamine receptor H
1
(H
1
R) is a susceptibility gene in both experimental autoimmune encephalomyelitis (EAE) and experimental autoimmune orchitis (EAO), 2 classical T cell–mediated models of organ-specific autoimmune disease. Here we showed that expression of H
1
R in naive CD4
+
T cells was required for maximal IFN-γ production but was dispensable for proliferation. Moreover, H
1
R signaling at the time of TCR ligation was required for activation of p38 MAPK, a known regulator of IFN-γ expression. Importantly, selective reexpression of H
1
R in CD4
+
T cells fully complemented both the IFN-γ production and the EAE susceptibility of H
1
R-deficient mice. These data suggest that the presence of H
1
R in CD4
+
T cells and its interaction with histamine regulates early TCR signals that lead to Th1 differentiation and autoimmune disease.
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Details
- Title
- Histamine receptor H1 is required for TCR-mediated p38 MAPK activation and optimal IFN-γ production in mice
- Creators
- Rajkumar Noubade - Department of Medicine and Department of Pathology, University of Vermont, Burlington, Vermont, USAGraeme Milligan - Department of Medicine and Department of Pathology, University of Vermont, Burlington, Vermont, USAJames F Zachary - Department of Medicine and Department of Pathology, University of Vermont, Burlington, Vermont, USAElizabeth P Blankenhorn - Department of Medicine and Department of Pathology, University of Vermont, Burlington, Vermont, USARoxana del Rio - Department of Medicine and Department of Pathology, University of Vermont, Burlington, Vermont, USAMercedes Rincon - Department of Medicine and Department of Pathology, University of Vermont, Burlington, Vermont, USACory Teuscher - Department of Medicine and Department of Pathology, University of Vermont, Burlington, Vermont, USA
- Publication Details
- The Journal of clinical investigation, v 117(11), pp 3507-3518
- Publisher
- American Society for Clinical Investigation
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:000250676000043
- Scopus ID
- 2-s2.0-36049045011
- Other Identifier
- 991014878023104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Medicine, Research & Experimental