Journal article
Histamine receptor H1 is required for TCR-mediated p38 MAPK activation and optimal IFN-γ production in mice
Nov 2007
Abstract
Histamine receptor H1 (H1R) is a susceptibility gene in both experimental autoimmune encephalomyelitis (EAE) and experimental autoimmune orchitis (EAO), 2 classical T cell mediated models of organ-specific autoimmune disease. Here we showed that expression of H 1 R in naive CD4 + T cells was required for maximal IFN-γ production but was dispensable for proliferation. Moreover, H 1 R signaling at the time of TCR ligation was required for activation of p38 MAPK, a known regulator of IFN-γ expression. Importantly, selective reexpression of H1R in CD4 + T cells fully complemented both the IFN-γ production and the EAE susceptibility of H 1 R-deficient mice. These data suggest that the presence of H1R in CD4 + T cells and its interaction with histamine regulates early TCR signals that lead to Th1 differentiation and autoimmune disease.
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Details
- Title
- Histamine receptor H1 is required for TCR-mediated p38 MAPK activation and optimal IFN-γ production in mice
- Creators
- R NoubadeG MilliganJ.F ZacharyE.P BlankenhornR del RioM RincornC Teuscher
- Publisher
- Americal Society for Clinical Investigation
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Identifiers
- 991019231724804721