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Histological examination of focused ultrasound effects on human brain tissue
Journal article   Open access   Peer reviewed

Histological examination of focused ultrasound effects on human brain tissue

Norman M Spivak, Alexander S Korb, Samuel D Reyes, Brendan P Bych, Samantha F Schafer, Négar Khanlou, Eric A Johnson, Mark E Schafer, Mark S Cohen, Taylor Kuhn, …
Brain stimulation, v 14(6), pp 1486-1488
Nov 2021
PMID: 34607066
url
https://doi.org/10.1016/j.brs.2021.09.015View
Published, Version of Record (VoR)CC BY V4.0 Open

Abstract

Of recent interest in neuromodulation is the use of Low Intensity Focused Ultrasound [1] (FUS), itself a topic of significant interest and of several experiments conducted recently in humans with FUS [2],[3]. The FDA Guidance on acoustic output for diagnostic ultrasound limits the derated spatial-peak temporal-average ultrasound intensity (ISPTA.3) to 0.72 W/cm2. Much of the human neuromodulation work has been conducted at this limit [2]. However, as this threshold was established principally for diagnostic, as opposed to therapeutic ultrasound, some groups have conducted research at higher intensities [4], upwards of 6.16 W/cm2 to understand better what range of intensities is most effective for neurostimulation. With higher intensities comes a greater risk of non-reversible injury to the tissue, such as thermal or mechanical damage including cavitation [5] and apoptosis [6]. With this in mind, we designed the present study to investigate the effects of focused ultrasound on human brain tissue to assess intensities at which focused ultrasound might cause irreversible structural cell damage. Because of the possibility that high ultrasound intensities might be destructive, we worked exclusively on excised tissue.

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Collaboration types
Domestic collaboration
Web of Science research areas
Clinical Neurology
Neurosciences
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