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Journal article
Histological examination of focused ultrasound effects on human brain tissue
Brain stimulation, v 14(6), pp 1486-1488
Nov 2021
PMID: 34607066
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Of recent interest in neuromodulation is the use of Low Intensity Focused Ultrasound [1] (FUS), itself a topic of significant interest and of several experiments conducted recently in humans with FUS [2],[3]. The FDA Guidance on acoustic output for diagnostic ultrasound limits the derated spatial-peak temporal-average ultrasound intensity (ISPTA.3) to 0.72 W/cm2. Much of the human neuromodulation work has been conducted at this limit [2]. However, as this threshold was established principally for diagnostic, as opposed to therapeutic ultrasound, some groups have conducted research at higher intensities [4], upwards of 6.16 W/cm2 to understand better what range of intensities is most effective for neurostimulation. With higher intensities comes a greater risk of non-reversible injury to the tissue, such as thermal or mechanical damage including cavitation [5] and apoptosis [6]. With this in mind, we designed the present study to investigate the effects of focused ultrasound on human brain tissue to assess intensities at which focused ultrasound might cause irreversible structural cell damage. Because of the possibility that high ultrasound intensities might be destructive, we worked exclusively on excised tissue.
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Details
- Title
- Histological examination of focused ultrasound effects on human brain tissue
- Creators
- Norman M Spivak - University of California Los AngelesAlexander S Korb - University of California Los AngelesSamuel D Reyes - University of California Los AngelesBrendan P Bych - University of California Los AngelesSamantha F Schafer - Drexel UniversityNégar Khanlou - University of California Los AngelesEric A Johnson - University of California Los AngelesMark E Schafer - Drexel UniversityMark S Cohen - University of California Los AngelesTaylor Kuhn - University of California Los AngelesAlexander Bystritsky - University of California Los Angeles
- Publication Details
- Brain stimulation, v 14(6), pp 1486-1488
- Publisher
- Elsevier
- Number of pages
- 3
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000711352200001
- Scopus ID
- 2-s2.0-85116506176
- Other Identifier
- 991019168556004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Neurosciences