Journal article
Histone deacetylase inhibitors prevent oxidative neuronal death independent of expanded polyglutamine repeats via an Sp1-dependent pathway
Proceedings of the National Academy of Sciences - PNAS, v 100(7), pp 4281-4286
01 Apr 2003
PMID: 12640146
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Oxidative stress is believed to be an important mediator of neurodegeneration. However, the transcriptional pathways induced in neurons by oxidative stress that activate protective gene responses have yet to be fully delineated. We report that the transcription factor Sp1 is acetylated in response to oxidative stress in neurons. Histone deacetylase (HDAC) inhibitors augment Sp1 acetylation, Sp1 DNA binding, and Sp1-dependent gene expression and confer resistance to oxidative stress-induced death
in vitro
and
in vivo
. Sp1 activation is necessary for the protective effects of HDAC inhibitors. Together, these results demonstrate that HDAC inhibitors inhibit oxidative death independent of polyglutamine expansions by activating an Sp1-dependent adaptive response.
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Details
- Title
- Histone deacetylase inhibitors prevent oxidative neuronal death independent of expanded polyglutamine repeats via an Sp1-dependent pathway
- Creators
- Hoon Ryu - Department of Neurology andJunghee Lee - Department of Neurology andBeatrix A Olofsson - Department of Neurology andAziza Mwidau - Department of Neurology andAlpaslan Deodoglu - Department of Neurology andMaria Escudero - Department of Neurology andErik Flemington - Department of Neurology andJane Azizkhan-Clifford - Department of Neurology andRobert J Ferrante - Department of Neurology andRajiv R Ratan - Department of Neurology and
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, v 100(7), pp 4281-4286
- Publisher
- The National Academy of Sciences
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000182058400133
- Scopus ID
- 2-s2.0-0037386621
- Other Identifier
- 991014877678904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology