Journal article
Histopathologic variables predict Oncotype DX (TM) Recurrence Score
Modern pathology, v 21(10), pp 1255-1261
01 Oct 2008
PMID: 18360352
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Oncotype DX (TM) is a commercially available reverse transcriptase-polymerase chain reaction based assay that provides a Recurrence Score (RS) and has been shown to provide prognostic and predictive information in estrogen receptor-positive lymph node-negative breast cancers. Independent studies of its utility in routine practice are lacking. Slides and surgical pathology reports from 42 cases of breast carcinomas evaluated by Oncotype DX (TM) were retrospectively reviewed to determine patient age, tumor size, histologic grade, estrogen and progesterone receptor (ER and PR) and ERBB2 (HER-2/neu) data, with ER and PR reported as a semi-quantitative score reflecting both intensity of staining and proportion of positive cells. We show here that Recurrence Score is significantly correlated with tubule formation, nuclear grade, mitotic count, ER immunohistochemical score, PR immunohistochemical score, and HER-2/neu status, and that the equation RS = 13.424 + 5.420 (nuclear grade) +5.538 (mitotic count) -0.045 (ER immunohistochemical score) -0.030 (PR immunohistochemical score) +9.486 (HER-2/neu) predicts the Recurrence Score with an R(2) of 0.66, indicating that the full model accounts for 66% of the data variability. Although the Oncotype DX (TM) Recurrence Score holds potential, further validation of its independent value beyond that of histopathologic analysis is necessary before it can be implemented in clinical decision making.
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Details
- Title
- Histopathologic variables predict Oncotype DX (TM) Recurrence Score
- Creators
- Melina B. Flanagan - University of PittsburghDavid J. Dabbs - University of PittsburghAdam M. Brufsky - University of PittsburghSushil Beriwal - University of PittsburghRohit Bhargava - University of Pittsburgh
- Publication Details
- Modern pathology, v 21(10), pp 1255-1261
- Publisher
- Springer Nature
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:000259445200009
- Scopus ID
- 2-s2.0-52549110816
- Other Identifier
- 991021897275504721
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- Web of Science research areas
- Pathology