Journal article
History of Infertility and Risk of Endometrial Cancer in the Women's Health Initiative
Cancer epidemiology, biomarkers & prevention, v 33(12), pp 1683-1689
02 Dec 2024
PMID: 39348095
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Several studies have suggested an association between infertility and risk of endometrial cancer. However, most studies have evaluated this relationship in premenopausal people, yet the mean age of endometrial cancer is 60 years, after the average age of menopause.
Our study included Women's Health Initiative participants who self-reported whether they had a history of infertility. Cox proportional hazards models were used to examine the association between infertility and incident endometrial cancer. Given that all infertility diagnoses occurred prior to study enrollment, we conducted secondary analyses using logistic regression examining prevalent endometrial cancer cases diagnosed before study baseline.
Approximately 18% of participants reported a history of infertility. No statistically significant association was observed between infertility and risk of incident endometrial cancer overall [incident cases = 1,622; HR = 1.12; 95% confidence interval (CI) = 0.99-1.26]. Although point estimates suggested an increase in risk of endometrial cancer among women with body mass index (BMI) ≥25 (HR = 1.15; 95% CI = 0.99-1.33), none of the associations were statistically significant. There was an association between history of infertility and prevalent endometrial cancer cases (OR = 1.19; 95% CI = 1.06-1.34), with the strongest association for infertility diagnosis due to endometriosis (OR 2.42; 95% CI = 1.83-3.19).
In a population of postmenopausal participants, we observed a modest, but not statistically significant, association between overall infertility and incident endometrial cancer, with the suggestion of a higher risk among those with a BMI ≥ 25.
Our findings highlight, as observed in previous studies, that risk factors for endometrial cancer may vary by BMI.
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Details
- Title
- History of Infertility and Risk of Endometrial Cancer in the Women's Health Initiative
- Creators
- Holly R Harris (Corresponding Author) - University of WashingtonKathylynn Saboda - University of ArizonaCynthia A Thomson - University of ArizonaNazmus Saquib - Sulaiman Al Rajhi CollegesAladdin H Shadyab - Human Longevity (United States)Peter F Schnatz - Reading HospitalRogelio Robles-Morales - University of ArizonaLihong Qi - University of California, DavisDenise J Roe - University of ArizonaLeslie V Farland - University of Arizona
- Publication Details
- Cancer epidemiology, biomarkers & prevention, v 33(12), pp 1683-1689
- Publisher
- American Association for Cancer Research
- Grant note
- HHSN268201600018C / NHLBI NIH HHS R03 HD102403 / NICHD NIH HHS HHSN268201600003C / NHLBI NIH HHS HHSN268201600004C / NHLBI NIH HHS HHSN268201600002C / NHLBI NIH HHS P30 CA093373 / NCI NIH HHS HHSN268201600001C / NHLBI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering and Science
- Web of Science ID
- WOS:001368635600008
- Scopus ID
- 2-s2.0-85211000582
- Other Identifier
- 991022202104804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Oncology
- Public, Environmental & Occupational Health