Journal article
Homocysteine and Pulsatility Index of Cerebral Arteries
Stroke (1970), v 40(10), pp 3216-3220
01 Oct 2009
PMID: 19628800
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Abstract
Background and Purpose-A pulsatility index (PI) represents vascular resistance distal to an examined artery. The purpose of the present study was to evaluate an association between plasma total homocysteine (tHcy) and PIs of the cerebral arteries in patients with ischemic stroke.
Methods-Consecutive patients with ischemic stroke referred to a neurovascular ultrasound laboratory were evaluated from March 2007 to February 2008. PI was defined as (peak systolic velocity-end-diastolic velocity)/mean flow velocity as recommended. Transcranial Doppler was examined in both middle cerebral arteries and vertebral arteries, and basilar arteries. All patients with ischemic stroke were subdivided according to the presence of proximal internal carotid arterial steno-occlusion (ICS).
Results-The numbers of patients enrolled for the present analysis as ischemic stroke without and with ICS were 272 and 92, respectively. PIs measured in the cerebral arteries did not show a significant difference in the two groups, in spite of the fact that mean flow velocities of both basilar arteries and vertebral arteries were significantly elevated in the patients with ICS. Plasma tHcy was found to be independently associated with graded increases of PIs in all cerebral arteries in the patients without ICS, even adjusted for the potential confounders. However, there was no association between tHcy and PI in the patients with ICS.
Conclusion-Plasma tHcy was directly associated with increased cerebral arterial resistance. But in clinical situations when the cerebral arterial hemodynamics were altered as in the patients with ICS, the effect of tHcy on arterial remodeling could be obscured. (Stroke. 2009;40:3216-3220.)
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Details
- Title
- Homocysteine and Pulsatility Index of Cerebral Arteries
- Creators
- Mi-Hye Lim - Jeonbuk National UniversityYoung I. Cho - Drexel UniversitySeul-Ki Jeong - Chonbuk Natl Univ, Med Sch & Hosp, Dept Neurol, Jeonju 561180, Jeonbuk, South Korea
- Publication Details
- Stroke (1970), v 40(10), pp 3216-3220
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 5
- Grant note
- Research Institute of Clinical Medicine, Chonbuk National University Hospital.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000270229800011
- Scopus ID
- 2-s2.0-70349653326
- Other Identifier
- 991019167604204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Clinical Neurology
- Peripheral Vascular Disease