Journal article
Homocysteine and pulsatility index in lacunar infarction
Clinical neurology and neurosurgery, v 113(6), pp 459-463
01 Jul 2011
PMID: 21371817
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective: To evaluate an association between plasma concentration of total homocysteine (tHcy) and pulsatility indexes (Pis) of cerebral arteries in patients with lacunar infarction (LI), comparing control subjects.
Methods: Consecutive patients referred to a neurovascular ultrasound laboratory were evaluated from March 2007 to February 2008. LI was determined by high signal intensity lesion (<15 mm) in brain MRI and PI was defined as (peak-systolic velocity - end-diastolic velocity)/mean flow velocity as recommended. Plasma tHcy was categorized into tertiles and analyzed for an association with PIs.
Results: 83 patients with LI and 135 control subjects were analyzed. The patients with LI showed significantly lower peak-systolic, end-diastolic, and mean flow velocities than the control group, especially in posterior circulatory beds. The group with LI showed independent associations between the higher tertiles of tHcy and the graded and linear increases of PIs, even after adjusted for potential confounders including vascular risk factors, but not in the control group. Interaction terms were significant in both the right middle cerebral artery and basilar artery, and borderline significant in the left vertebral artery (p = 0.040, 0.022, 0.055, respectively).
Conclusion: Increased plasma tHcy was significantly and independently associated with increased cerebral arterial resistance in the patients with LI. (C) 2011 Elsevier B.V. All rights reserved.
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Details
- Title
- Homocysteine and pulsatility index in lacunar infarction
- Creators
- Seul-Ki Jeong - Jeonbuk National UniversityDo-Hyung Kim - Jeonbuk National UniversityYoung I. Cho - Drexel University
- Publication Details
- Clinical neurology and neurosurgery, v 113(6), pp 459-463
- Publisher
- Elsevier
- Number of pages
- 5
- Grant note
- Research Institute of Clinical Medicine, Chonbuk National University Hospital
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000292437100005
- Scopus ID
- 2-s2.0-79958085530
- Other Identifier
- 991019167567104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Clinical Neurology
- Surgery