Journal article
Hooks and comets: The story of microtubule polarity orientation in the neuron
Developmental neurobiology (Hoboken, N.J.), Vol.71(6), pp.403-418
Jun 2011
PMCID: PMC3151545
PMID: 21557497
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
It is widely believed that signature patterns of microtubule polarity orientation within axons and dendrites underlie compositional and morphological differences that distinguish these neuronal processes from one another. Axons of vertebrate neurons display uniformly plus-end-distal microtubules, whereas their dendrites display non-uniformly oriented microtubules. Recent studies on insect neurons suggest that it is the minus-end-distal microtubules that are the critical feature of the dendritic microtubule array, whether or not they are accompanied by plus-end-distal microtubules. Discussed in this article are the history of these findings, their implications for the regulation of neuronal polarity across the animal kingdom, and potential mechanisms by which neurons establish the distinct microtubule polarity patterns that define axons and dendrites.
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Details
- Title
- Hooks and comets: The story of microtubule polarity orientation in the neuron
- Creators
- Peter W Baas - Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA. pbaas@drexelmed.eduShen Lin
- Publication Details
- Developmental neurobiology (Hoboken, N.J.), Vol.71(6), pp.403-418
- Publisher
- Wiley; United States
- Grant note
- R01 NS028785-24 / NINDS NIH HHS R01 NS028785 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Identifiers
- 991014877960404721
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- Web of Science research areas
- Developmental Biology
- Neurosciences